轻度氧化LDL在动脉粥样硬化早期病变中的作用  

The effects of mildly modified low density lipo-protein on the early lesions of atherosclerosis

作　　者：朱宇[1] 蔡海江[1] 陈秀英[1] 范乐明[1] 姜传仓 王南[1] 

机构地区：[1]南京医学院动脉粥样硬化研究中心

出　　处：《中国病理生理杂志》1995年第2期174-178,共5页Chinese Journal of Pathophysiology

摘　　要：本文发现轻度氧化ＬＤＬ（ｍｍ－ＬＤＬ）可促进ＨＬ６０细胞与牛主动脉内皮细胞粘附，其作用程度与氧化修饰ＬＤＬ（Ｏｘ－ＬＤＬ）无明显差异。还发现ｍｍ－ＬＤＬ可明显提高巨噬细胞、平滑肌细胞中胆固醇酯的蓄积，但程度低于Ｏｘ－ＬＤＬ的作用。细胞上ＬＤＬ受体活性及基因表达可随细胞与ｍｍ－ＬＤＬ或Ｏｘ－ＬＤＬ孵育时间延长表现出下行性调节，从另一侧面证明细胞内存在脂质蓄积。It was found that mildly modified LDL(mm-LDL)induced adherence ofHL60 monocytes to bovine aort ic endothelial cells with out significant difference fromoxidized LDL( OX-LDL).The accumulation of cholesteryl ester was also enhanced bymm-LDL in macrophages and in smooth muscle cells significantly,but not as efficientas Ox-LDL. The activity and gene expression of LDL receptors was decreasing whilethe incubating time of cells with mm-LDL or Ox-LDL was prolonged,These also indicatelipid accumulation in cells.

关 键 词：动脉粥样硬化 低密度脂蛋白 

分 类 号：R541.402[医药卫生—心血管疾病]