过敏性哮喘豚鼠血小板激活因子的变化及川芎嗪的影响  

Changes of platelet- activating factor in allergic asthmatic guinea pigs and effect of Ligustrazin

作　　者：于化鹏[1] 李平升[1] 府军[1] 

机构地区：[1]第一军医大学珠江医院呼吸科,第二军医大学长海医院呼吸科

出　　处：《中国病理生理杂志》1995年第3期317-320,共4页Chinese Journal of Pathophysiology

摘　　要：本研究采用生物定量测定方法观察了豚鼠实验性哮喘时血浆ｌｙｓｏ－ｐＡＦ和肺泡灌洗液（ＢＡＬＦ）中ＰＡＦ的变化。结果显示：致敏组豚鼠哮喘发作时血浆ｌｙｓｏ－ＰＡＦ水平显著高于对照组（Ｐ＜０．０１），ＢＡＬＦ中ＰＡＦ水平也明显高于对照组（Ｐ＜０．０５），同时伴有血浆及ＢＡＬＦ中ＴＸＢ＿２、ＴＸＢ＿２／６－酮－ｐＧＦ１α水平的升高（Ｐ＜０．０１）。致敏＋川芎嗪组豚鼠血浆ｌｙｓｏ－ｐＡＦ明显低于致敏组豚鼠（Ｐ＜０．０５），其ＢＡＬＦ中ＰＡＦ水平也有明显降低（Ｐ＜０．０５）。提示过敏性哮喘豚鼠发作期ＰＡＦ产生增多，川穹嗪对ＰＡＦ的产生具有一定的抑制作用。Platelet-activating factor(PAF)is a potent inflammatory mediator.It wasdemonstrated that PAF may cause bronchoconstriction and increase vascular permeabilityin animal and human being.In order to investigate the role of PAF and its possiblemechanism in allergic asthma,the concentration of PAF in plasma and bronchoalveolarlavage fluid(BALF)of allergy asthmatic guinea pigs were observed.It was found that theplasma levels of lyso-PAF、TXB_2、TXB_2/6-keto-PGF_(1α) and the concentration of PAF,TXB_2、TXB￣2/6-keto-PG_(1α),a in BALF increased significantly(P<0.01)in sensitized group,but 6-keto-PGF_(1α) decreased remarkably(P<0.05). However,in sensitized + ligustrazingroup,ligustrazin relieved the symptoms and inhibited the production of PAF,lyso-PAFand TXB_2 in plasma and BALF.It was concluded that PAF play an important role inallergic asthma and ligustrazin had some good effects in preventing experimental asthma.

关 键 词：哮喘 血小板激活因子 川芎嗪 

分 类 号：R562.250.2[医药卫生—呼吸系统] R363.13[医药卫生—内科学]