脑脊液高碳酸血症后碱中毒与利尿剂的应用研究  

A study of acute posthypercapnic alkalosis of cerebrospinal fluid and use of diuretics

作　　者：金发光[1] 钱桂生[1] 邵丽丽[1] 赵自强[1] 

机构地区：[1]第三军医大学新桥医院全军呼吸专科中心

出　　处：《中国病理生理杂志》1995年第3期286-290,共5页Chinese Journal of Pathophysiology

摘　　要：本研究动态观察了犬急性呼吸性酸中毒动脉血和ＣＳＦ酸碱变量。动脉血酸碱变量在８ｈ实验过程中３组均无明显差异（Ｐ＞０．０５）。ＣＳＦｐＣＯ＿２的变化值同动脉血相似，但ＣＳＦ［ＨＣＯ＿３－］在３组之间有显著性差异（Ｐ＜０．０１）。Ⅰ、Ⅱ、Ⅲ组ＣＳＦ［ＨＣＯ＿３－］８ｈ分别增加了６、１．２和８ｍｍｏｌ／Ｌ。结果表明急性呼吸性酸中毒迅速纠正后，ＣＳＦ发生了代谢性碱中毒。乙酰唑胺能预防和治疗ＣＳＦ高碳酸血症后碱中毒，速尿可诱发和加重ＣＳＦ高碳酸血症后碱中毒。The mechanism of acute posthypercapnic alkalosis of cerebrospinal fluid(CSF)and the effects of diuretics on it was studied. Arterial blood and CSF acid-base.variables in three groups(n=5 each ) of dogs were measured.During hypercapnia,arte-rial pCO_2 and plasma[HCO_3-]in all three groups had no significant statisiticallychanges. The increase in CSF pCO_2 was similar.However,changes in CSF[HCO_3-]between the three groups were significantly different.In group Ⅰ,Ⅱ,and Ⅲ,CSF[HCO_3-]increased by 6,1.2 and 8 mmol/L respectively at 8th kour.It was concluded that CSFinduced posthypercapnic alkalosis after acute respiratory acidosis was corrected.Acetazoa-mide was able to prevent and treat acute posthypercapnic alkalosis of CSF ,while furose-mide can induce and worsen it.

关 键 词：酸中毒 碱中毒 乙酰唑胺 呋罗酰胺 脑脊液 

分 类 号：R589.605[医药卫生—内分泌] R589.602[医药卫生—内科学]