急性缺氧对膈肌疲劳的影响  

Effect of acute hypoxemia on diaphragmatic fatigue

作　　者：史依仁[1] 郭先健[1] 赵自强[1] 

机构地区：[1]重庆第三军医大学新桥医院呼吸中心

出　　处：《中国病理生理杂志》1995年第5期543-546,共4页Chinese Journal of Pathophysiology

摘　　要：本文观察急性缺氧对犬膈肌疲劳的影响，发现急性缺氧条件下，膈肌疲劳的耐受时间为１８．００±３．７０ｍｉｎ，较对照组４１．３３±５．３０ｍｉｎ明显缩短（Ｐ＜０．０５），而且疲劳膈肌恢复过程中产生跨膈压（ｔｒａｎｓｄｉａｐｈｒａｇｍａｔｉｃｐｒｅｓｓｕｒｅ，Ｐｄｉ）明显低于对照组（Ｐ＜０．０５），证实急性缺氧使膈肌疲劳的耐受性明显下降，且不利于疲劳膈肌肌力的恢复。Ten dogs were randomly divided into two groups in order to observe theeffect of acute hypoxemia on canine diaphragmatic fatigue. In hypoxemia group(n=5),diaphragmatic fatigue was produced during hypoxemia while the control group(n=5)was breathing room air.It was found that:1) hypoxemia group had much shorterendurance time than control group;2 )at 60, 120 min after fatigue,the transdiaphrag-matic pressure(Pdi)at all frequency of stimulation in hypoxemia group was less thanthat in control group.It is concluded that acute hypoxemia not only increased the dia-phragmatic fatigue but also delayed the recovery of diaphragmatic fatigue.

关 键 词：膈肌 疲劳 缺氧 

分 类 号：R594.302[医药卫生—内科学]