裸鼠实验性矽结节形成与免疫应答关系的探讨  

The effect of silica treatment on nu/nu mice immunological function

作　　者：林晨[1] 杨柳[1] 张文兴[1] 司徒锐[1] 王惠华[1] 廖剑辉[1] 

机构地区：[1]暨南大学医学院微生物和免疫学教研室,暨南大学医学院病理学教研室

出　　处：《中国病理生理杂志》1995年第6期615-618,共4页Chinese Journal of Pathophysiology

摘　　要：先天性胸腺缺陷的裸鼠及正常ＢＡＬＢ／ｃ小鼠腹腔注射二氧化硅（ＳｉＯ＿２）后，连续８周动态观察血清ＩｇＭ，ＩｇＧ，抗ｓｓＤＮＡ抗体的变化及其与矽结节形成的关系，结果表明：两组实验鼠在形成矽结节过程中，免疫反应不同，ＢＡＬＢ／Ｃ鼠诱导形成的矽结节明显大于裸鼠组，ＢＡＬＢ／ｃ组鼠血清ＩｇＭ，ＩｇＧ，裸鼠组血清ＩｇＭ明显升高，两组鼠抗ｓｓＤＮＡ抗体均异常升高，ＢＡＬＢ／ｃ鼠组抗ｓｓＤＮＡ抗体阳性率明显高于裸鼠组，结果说明Ｔ细胞在矽结节形成过程中有一定作用，血清抗体的异常升高作为继发因素参与矽结节形成。The silicotic nodules were induced by silica intraperitoneal injection in nu/nu mice and BALB/c mice.In 8 weeks,the size of silicatic nodules induced in BALB/cmice was bigger than that of the nu/nu mice.The serum titer of IgM,IgG antibodies inBALB/c and IgM in nu/nu mice were higher than that of the control.The high level of IgGantibody in BALB/c mice maintained at least for 8 weeks.The titer of anti-ssDNA anti- body was high in both mice,but the positive reactivity of anti-ssDNA antibody in BALB/cwas greater than that of nu/nu mice.These results indicated that the T cells might beresponsible for inducing silicotic noludes.The abnormalties of serum antibodies may haveresulted from the silica stimulation.The autoantibody may have stimulated the formationof the silicatic nodules.

关 键 词：硅石 免疫 矽结节 矽肺 

分 类 号：R135.2[医药卫生—劳动卫生]