容量和压力负荷时心肌胶原增生与心肌血管紧张素Ⅱ的关系  

Hyperplasia of myocardial collagen and its relation to myocardial angiotensin Ⅱ in rats during pressure and Volume overload

作　　者：田斌[1] 黄英 高广道[1] 卢兴[1] 

机构地区：[1]西安医科大学病理生理教研室,北京医科大学第三医院血管医学研究所

出　　处：《中国病理生理杂志》1995年第6期573-577,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金;"八.五"攻关资助

摘　　要：对于机械负荷，尤其是容量负荷增加时，心肌胶原发生何种改变以及其机制如何，目前尚不十分清楚。本文验采用放射免疫及生化等方法，就大鼠动－静脉瘘（ＡＶＦ）和主动脉狭窄（ＡＣ）时，心肌和血浆血管紧张素Ⅱ（ＡｎｇⅡ）含量、心肌胶原总量（ＴＣＣ）、含量（ＣＣ）及Ⅰ／Ⅲ型胶原比值的变化进行初步研究。发现在心肌ＡｎｇⅡ明显升高的同时，ＡＶＦ大鼠术后五周不仅心／体比值（Ｖ／ＢＷ）明显升高，其左右室ＴＣＣ和ＣＣ也显著增加，但Ⅰ／Ⅲ比值无明显改变。ＡＣ大鼠从术后两周起，Ｖ／ＢＷ、左右室ＴＣＣ、ＣＣ及Ⅰ／Ⅲ比值就显著高于对照组。而两种模型大鼠血浆ＡｎｇⅡ未见升高。提示：１．容量超负荷持续一定时间后可导致心肌胶原明显增生，且Ⅰ和Ⅲ型胶原增生程度基本成正比例；２．心肌ＡｎｇⅡ在两种负荷增加所致心肌胶原增生中可能起着重要作用。The mechanisms of the changes of heart collagens which were caused byhemodynamic overload,especially by volume-overload,still remained in suspending.Toapproach this end,the changes of ventricular and plasma angtotensin( Ang)Ⅱ content,total heart collagen content(TCC ),collagen concentration(CC)and the ratio of Ⅰ:Ⅲcollagen types(Ⅰ/Ⅲ)in aorta-constriction(AC)and aortacava fistula(ACF)ratsWere determined by means of radioimmunoassay and biochemical methods.It was foundthat not only the ratio of ventricle wet weight to body weight( V/BW)increased ob- viously,but also the TCC and CC in both left and right ventricles enhanced significan-tly,combined with the increase of ventricular AngⅡ content(whereas the Ⅰ/Ⅲ remainedunchanged ).In AC rats,associated with the increase of ventricular Ang Ⅱ,the V/BW,TCC,CC and Ⅰ/Ⅲincreased significantly two-weeks after the surgery·No enhan- cement of plasma AngⅡ in AC or ACF rats.These findings suggested that:1.Obvioushyperplasia of heart collagens occured after volume-overload and the hyperplasia of Ⅰand Ⅲ collagen types was generally in an hemogeneous fashion;2 .Local producedAng Ⅱmay play a cornerstone role in hyperplasia of heart collagens during pressureor volume overload.

关 键 词：血管紧张素 胶原 心肌疾病 

分 类 号：R542.202[医药卫生—心血管疾病]