肿瘤坏死因子在大鼠内毒素性肺损伤中作用的研究  

Effect of tumor necrosis factor on endotoxin─ induced acute lung injury in rats

作　　者：孙耕耘[1] 毛宝龄[1] 吕宝璋[1] 

机构地区：[1]重庆第三军医大学二院呼吸内科,军事医学科学院基础所

出　　处：《中国病理生理杂志》1995年第6期646-649,共4页Chinese Journal of Pathophysiology

摘　　要：本实验观察到，给大鼠静脉注射５ｍｇ／ｋｇ或０．５ｍｇ／ｋｇ内毒素后，其血清ＴＮＦα浓度的均值相近，但小剂量内毒素（０．５ｍｇ／ｋｇ）并不能诱导大鼠肺损伤；直接静注ｒＨＴＮＦα也不能致大鼠急性肺损伤；表明本实验所测到的ＴＮＦα升高与内毒素诱导的急性肺损伤无直接因果关系。将内毒素与ｒＨＴＮＦα同时静注，显著增加大鼠４ｈ死亡率，提示ｒＨＴＮＦα加强内毒素的毒性效应。It was observed that the mean concentrations of serum tumor necrosisfactor α(TNFα)in the rats were similar after intravenous injections of 5mg/kg and 0.5mg/kg endotoxin respectively. Nevertheless, a small dose of endotoxin(0.5mg/kg )couldnot induce lung injury in rats, and neither could the intravenous injection of rHTNFα.These results indicate that there is no direct relationship between TNFα elevation andendotoxin─induced acute lung injury in rats. Coadministration of endotoxin and rHTNFαmarkedly increased the 4th hour mortality of the rats, which suggested that rHTNFαwould enhance the toxic effects of endotoxin.

关 键 词：肿瘤坏死因子 肺损伤 内毒素 

分 类 号：R563.02[医药卫生—呼吸系统]