慢性氟中毒大鼠肝细胞超微结构改变的体视学研究  

A STEREOLOGIC STUDY OF HEPATOCYTIC ULTRASTRUCTURE ON RAT CHRONIC FLUOROSIS

作　　者：郑淑芳[1] 张瑞祥[1] 郑纪宁[1] 刘胜[1] 张乃鑫[2] 章鸣放[2] 王晓燕[2] 

机构地区：[1]承德医学院 [2]天津医学院

出　　处：《中国地方病防治》1995年第1期4-6,共3页Chinese Journal of Control of Endemic Diseases

摘　　要：用体视学方法计量两组大鼠肝细胞线粒体的体密度(Vvm)、面密度(Svm)、比表面(Qm)、面数密度(N_(Am)、规化形状因子(RFF)。结果表明染氟组大鼠肝细胞线粒体RFF显著减少(P<0.01);Vvm、Svm显著增高(P<0.005);Qm无显著差异。提示NaF能引起肝细胞线粒体的畸形和增生。Using the stereologic method the following parameters of hepatocyte mitochondria were measured: volume density (Vvm) , surface density (Svm) , specific surface (Qm) , area number density (Nam) and regular form factor (RFF). The results showed : RFF in group F was very significantly decreased, Vvm, Svm in group F was very significantly increased and Qm in group F did not statistic difference. The results suggest that there may be compensatory proliferation and deformation of hepatocyte mitochondria in group F.

关 键 词：氟中毒 肝细胞 线粒体 体视学 超微结构 

分 类 号：R595.902[医药卫生—内科学]