氟对大鼠子代雄鼠睾丸生化毒作用的影响  

Biochemical effect of fluoride on testis in rats

作　　者：吴南屏[1] 赵忠良[1] 高文华[1] 

机构地区：[1]宁夏医学院预防医学系

出　　处：《中国地方病学杂志》1995年第5期261-262,共2页Chinese Jouranl of Endemiology

摘　　要：给Ｗｉｓｔａｒ大鼠孕期分别自由饮用０．６ｍｇ／Ｌ（对照组），２５ｍｇ／Ｌ含氟水，其子鼠（饮用同浓度含氟水）至７５ｄ，探讨胚胎期至生长发育期接触较高剂量氟对雄鼠性腺的影响。检测结果显示，在该染氟剂量和时间内，氟未引起睾丸组织脂质过氧化作用发生改变。但睾丸ＬＤＨ－Ｘ酶活性显著增高，唾液酸含量亦显著升高，血浆ＬＤＨ活性降低。表明氟可引起睾丸组织的生化功能改变．对睾丸组织的细胞有一定损伤作用，旦这种损伤作用似不是通过引起脂质过氧化造成的。Wistar rats were exposed to fluoride by drinking water from gestation to day 75.The biochemical function of testis of offspring rats was studied.The results showed that the activity of LDH-X increased in testis,and LDH activity in plasma was decreased significantly.The static acid level in testis tissue was increased significantly.The results suggested that fluorine could interfere with the biochemical funtion of testis and cause damage to testis tissue.

关 键 词：氟 睾丸 实验动物 氟中毒 子代 

分 类 号：R992[医药卫生—毒理学] R599.9[医药卫生—药学]