硒和VE对克山病病区粮及低硒人工合成饲料喂养大鼠心肌胰岛素含量的影响  

Effect of grains grown in Keshan Disease endemic area on insulin contents in myocardium of rats

作　　者：张桂珍[1] 任立群[1] 李广生[1] 王凡[1] 康德仁[1] 黄伦[1] 

机构地区：[1]白求恩医科大学地方病研究所,吉林市中心医院心血管科

出　　处：《中国地方病学杂志》1995年第6期330-333,共4页Chinese Jouranl of Endemiology

基　　金：国家"八五"攻关课题基金

摘　　要：饲予低硒克山病病区粮引起大鼠心肌细胞摄取胰岛素能力明显下降；在病区粮内补充一定剂量硒或维生素Ｅ可明显增加心肌细胞对胰岛素的摄取量（Ｐ＜０．０５～０．０１）；在亚硝酸钠引起的一过性缺氧条件下，单纯补硒或维生素Ｅ对心肌细胞摄取胰岛素能力无明显影响（Ｐ＞０．０５），只有联合补硒和维生素Ｅ才表现出统计学意义（Ｐ＜０．０１）；在低硒人工半合成饲料中补硒或维生素Ｅ均可显著增加心肌细胞摄取胰岛素能力（Ｐ＜０．０１）。本研究结果提示，克山病病区粮中的致病因素可原发性损害心肌细胞摄取胰岛素功能，此改变可能是病区粮引起克山病心肌损害重要环节之一。The se-deficient grains grown in Keshan Disease endemic area caused the decrease of insulin contents in myocardium of the rats. The diet supplemented with either selenium 0. 2mg/Kg diet or Vitamin E 500mg/Kg diet statistically increased the insulin contents in the myocardium (P<0. 05～0. 01). In ananoxie state by the injection of NaNO2, diets supplementation of selenium or Vitamin E failed to cause the obvious increase of the insulin contents and it was the combined supplementation of selenium and Vitamin E that apparently increased the insulin contents in myocardium of the rats. The results also demenstrsted salenium and Vitamin E deficiency was pathogeny of the decrease of the insulin contents.The study suggested the decrease of insulin contents in myocardium may be an important factor in causing KD myocardial necrosis.

关 键 词：克山病 心肌细胞 胰岛素 硒 维生素E 

分 类 号：R542.305[医药卫生—心血管疾病]