消斑肽能逆转平滑肌细胞源性泡沫细胞  

Xiaoban Peptide Can Reverse Smooth Muscle Cell-derived Foam Cell

作　　者：杨永宗[1] 杨小毅[1] 袁中华 

机构地区：[1]衡阳医学院心血管病研究所

出　　处：《中国动脉硬化杂志》1995年第4期275-278,共4页Chinese Journal of Arteriosclerosis

摘　　要：培养的猪主动脉平滑肌细胞，在与１０ｍｇ·Ｌ－１氧化型低密度脂蛋白作用７２ｈ后，细胞内蓄积胆固醇酯，使胆固醇酯占总胆固醇的６４．１％，形成泡沫细胞。然后向泡沫细胞的培养基中加入不同浓度的消斑肽，作用２４ｈ后，发现总胆固醇和胆固醇酯均下降，而且胆固醇酯小于总胆固醇的５０％，提示泡沫细胞发生了逆转。在平滑肌细胞源性泡沫细胞的形成过程中，一氧化氮合成增加，与对照组的差别有显著性，而在逆转过程中一氧化氨合成下降，与对照组差别无显著性，提示消斑肽有使一氧化氮合成功能恢复正常的作用。The cultured porcin artery smooth muscle cells became foam cells by preeincubated with 10 mg·L-1 oxidized low density lipoprotein for 72 hours, which could accumulate cholesteryl ester and the ratio between cholesteryl ester and total cholesterol was 64. 1%. When the foam cells were incubared with 0. 01 mg·L-1 and 0. 1mg·L-1 Xiaoban peptide for 24 hours, they reversed to normal smooth muscle cells, whose ratio between cholesteryl ester and total choles terol was less than 50%. The amount of nitric oxide increased in the medium of foam cell and decreased in the proess of reversing to normal level. It suggest that Xiaoban peptide may be a new antiatherosclerosis medicine.

关 键 词：消斑肽 泡沫细胞 平滑肌细胞 药理学 

分 类 号：R977.6[医药卫生—药品]