铅对作业工人某些内分泌腺功能影响的研究  

Effect of Lead on Function of Endocrine Glands in Workers Occupationally Exposed to Lead

作　　者：崔金山[1] 张玉敏[1] 李宏革[1] 苏雅[1] 孔庆芝[1] 田春寅 王春吉[1] 王虹飞 孙玉强[1] 

机构地区：[1]沈阳医学院毒理教研室,沈阳医学院附属二院内科,沈阳蓄电池厂职业病防治所,中国医科大学第一临床医院同位素科

出　　处：《中国工业医学杂志》1995年第1期1-3,共3页Chinese Journal of Industrial Medicine

摘　　要：本文研究发现铅吸收、铅中毒工人血中游离三碘甲状腺原氨酸（ＦＴ＿３）、游离四碘甲状腺原氨酸（ＦＴ－４）、皮质醇含量明显低于对照组工人（Ｆ＜０．０１），且与尿铅、尿δ－ＡＬＡ含量呈明显负相关；铅中毒工人血中ＴＳＨ明显高于对照组工人（Ｐ＜０．０１），且与尿铅、尿δ－ＡＬＡ含量呈明显正相关。结果提示，接铅工人体内铅负荷达铅吸收水平，但尚未产生中毒症状时就已影响了甲状腺、肾上腺皮质的分泌功能，说明某些内分泌腺对铅的损伤作用较敏感，铅损伤某些内分泌腺的功能可能是铅中毒的重要机理之一。In this paper, we studied effect of leadon function of some endocrine glands in wor-kers occupationally exposed to lead.The re-sults showed that the levels of FT3,FT4 and cortisol in serum were significantly lower in the group of lead poisoning and group of leadabsorption than in of the control group(P<0.01 )and showed negative correlation with levels of urinary lead and δ-ALA .The levels of TSH in serum was significantly higher in the group of lead poisoning than in the control group(P<0.01)and showed positive correla-tion with levels of urinary lead and δ-ALA .The results suggested that lead might impair the function of thyroid gland and adrenal co-rtex in lead over adsorption workers without symptoms of lead poisoning .It showed that some endocrine glands are sensitive to toxic effects of lead and impairment of some endo-crine glands by lead may be one of the impo-rtant mechanisms of lead poisoning .

关 键 词：铅吸收 铅中毒 职业病 内分泌腺功能 

分 类 号：R598.110.2[医药卫生—内科学]