心脑血管疾病患者脂蛋白(a)与ApoA_1、B的关系  

Relationship of Lipoprotein (a) and Apolipoprotein A_1,B in the Patients with Cerebral or Cardiovascular Diseases

作　　者：陈碧[1] 黄一镗 曾开淇[2] 杨俐丽[1] 林浪[3] 

机构地区：[1]福建医学院生物化学教研室,福州350004 [2]福建医学院附属第一医院,福州350004 [3]福建医学院营养与食品卫生教研室,福州350004

出　　处：《中国高血压杂志》1995年第1期34-36,共3页

摘　　要：测定150例急性脑血管病（其中脑出血51例．多发性脑梗塞56例，腔隙性梗塞43例），冠心病42例和高血压63例患者血清脂蛋白（a）及其血脂（AplA1、B、HDLc、TC和TG）含量。结果表明：多发性脑梗塞、脑出血和冠心病患者脂蛋白（a）水平与正常对照组比较明显升高（P＜0．01），其变化与其他血脂成分无相关性，支持Lp（a）为心脑血管疾病的独立危险因素。腔隙性梗塞和高血压Lp（a）升高不明显，脑出血患者血清ApoB和TC水平明显低于多发性脑梗塞（P＜0.01）。In this paper, we examined lipoprotein (a ) [Lp(a)] and other blood lipids from 150 patients with acute cerebral vessel disease (ACVD) in which there were 51 with cerebral hemorrhage (CH) and 56 multiple site cerebral infarction(MCI ), 43 lacunar infarct (L1 ), 42 coronary heart disease(CHD) and 63 hypertension (HT). The serum Lp (a) concentrations in the patients with MCI and CHD were significantlyhigher than those in age matched control normal subjects(P< 0. 01 ). No relationship between the level of serum Lp (a ) andother blood lipids was found suggesting that serum Lp(a ) maybe an independent risk factor in the development of cardiocerebrovascular disease. The serum ApoB and TC levels in CHwere markedly lower than those of MCI (P< 0. 05).

关 键 词：脂蛋白(a) 载脂蛋白 心脏血管疾病 脑血管疾病 

分 类 号：R540.2[医药卫生—心血管疾病] R743.02[医药卫生—内科学]