自发性高血压大鼠肥厚心肌血管紧张素Ⅱ受体的变化及其意义  

Changes and Significance of the Angiotensin Ⅱ Receptors in Left Ventricular Hypertrophic Myocardium in Spontaneously Hypertensive Rats

作　　者：孙旗[1] 张寄南[1] 杨国平[1] 杨迪[1] 马文珠[1] 王敬良[1] 

机构地区：[1]南京医科大学附属第一医院心血管病研究所,210029

出　　处：《中国高血压杂志》1995年第1期8-10,共3页

基　　金：国家自然科学基金!49270728

摘　　要：用3H－AngⅡ作为放射配基测定SHR和WKY大鼠心肌组织的AngⅡ受体。结果表明．多点法实验得到典型的饱和曲线，WKY组KD值为4．62±1．92nmol/L．Bmax值为103．75±9.23mol／mg蛋白；SHR组分别为5．18±214nmol／L及239．2±48．19fmol／mg蛋白。后者Bmax值明显高于前者。而KD值两组比较无明显差异。SHR组外周血醛固酮高于WKY组，两组AngⅡ值比较无明显差异。SHR大鼠心肌组织的超微结构发生变化。3H-angiotensin Ⅱ binding sites possessing the characteristics of a membrane recepter were identified in left ventricular myocardium membrane preparations from spontaneously hypertensive rats (SHR ) and Wistar-Kyoto rats (WKY). The results showed that typical multisite saturation curves were obtained and KD= 4. 62±1. 92 nmol/L and Bmax =103.75±19.28 fmol/mg protcin in WKY; KD=5.18±2.14 nmol/L and Bmax = 239. 21±48. 19 fmol/mg, protein in SHR.Bmax was significantly higher in SHR than that in WKY.Meanwhile, plasma aldosterone was higher in SHR than that in WKY. There was no difference in plasma angiotensin Ⅱ between the two groups. By observing the ultramicro-structure of myocardial tissue from SHR, the cxistence of LVH were confirmed. There was changes in the ultramicrostructure of myocardial tissue in SHR.

关 键 词：高血压 心肌肥厚 

分 类 号：R544.102[医药卫生—心血管疾病]