抗高血压因子的分布及其舒血管效应  

Distribution and Vasodilatory Effects of Erythrocyte Antihypertensive Factor

作　　者：王学谦[1] 文允镒[2] 张淑芳[2] 王群[2] 

机构地区：[1]天津医科大学附属第一中心医院,300192 [2]中国医学科学院基础医学研究所生理研究室,北京100005

出　　处：《中国高血压杂志》1995年第1期11-13,共3页

基　　金：中华医学基金会(CMB)资助!94022;中国医学科学院重点基金;国家自然科学基金!38970268

摘　　要：对抗高血压因子（AHF）的分布特点、不同种属来源的AHF降压效应和舒血管作用以及其是否为已知的血管活性物质等进行观察。结果表明，不论是人还是其他哺乳动物（如大鼠、免、狗等）的红细胞中均存在AHF。在剂量相同的情况下、AHF对大鼠的降压作用以及对大鼠主动脉的舒张作用五种属差异。随着AFH剂量的增加，其降压作用均呈明显的剂量依赖关系。不同剂量组间降压作用具有明显差异（P＜0．05或P＜0.01）。所观察的大鼠各种组织（如脑、心、肾、肝和红细胞等），以红细胞AHF的降压活性最高。多种已知的血管活性物质的特异受体拮抗剂只能阻断其相应的血管活性物质对血压的作用，对AHF的降压活性无影响。Effects of antihypertensive factor (AHF) from erythrocytes of human beings, rats, rabbits and dogs on the blood pressure (BP ) in rats were studied. Cornparative studies on the dcpressor effects of AHF from the heart, liver. kidney.brain and erythrocytes of rats were also investigated. The results showed that AHF from red blood cell (RBC ) of human beings and the animals at the doses of 0. 01, 0. 1 or 1. 0(mg/ kg) significantly decreased BP of rat in a dose-dependent manner. The AHF from erythrocyte had a greater depressor effect than preparation equivalent concentration of tissue extracts.AHF from RBC of the different animals at the doses of 40μg/ ml caused a sustained relaxation on phenylephrine-preconstricted rat aortic rings. Known vasoactive substance blockers could not alter the effect of AHF on BP. These data indicated that the effect of AHF on BP might be mediated via a specific receptor.

关 键 词：抗高血压因子 降压作用 舒血管作用 

分 类 号：R972.4[医药卫生—药品]