“拮氟锐”对氟拮抗作用的现场试验研究  

A Field trial of Anti-fluoride Effect of Jiefurui

作　　者：陈荣安 余达林[1] 张裕曾 宋世震 王胜 孙培莲 于忠言 王保华 

机构地区：[1]同济医大职业医学研究所,工业氟病防治研究协作组,同济医大协和医院

出　　处：《中国工业医学杂志》1995年第5期263-264,273,共3页Chinese Journal of Industrial Medicine

基　　金：中国有色金属总公司"八五"项目

摘　　要：８０名连续氟暴露５年以上的工人，按班组分为Ａ、Ｂ两组；同样以非氟暴露工人２０名为Ｃ组。Ａ组４２人口服拮氟锐复方剂，Ｂ组３８人未服药，均不脱离生产岗位，进行为期一个月的现场试验观察。结果表明，与未服药对照组比较，服药组工人尿中氟及氟硼酸根含量及排出量明显增高，血清碱性磷酸酶活性下降，血清Ｚｎ、Ｃｕ含量增加，血红细胞免疫粘附能力明显增强。提示拮氟锐有较明显的预防氟损伤效应。0 workers who had continous exposure tofiuoride for 5 or more than 5years were dividedinto two groups:group A 42 workers and groupB38 workers,The workers in group A tookjiefurui,a mixture made of boron,trace ele-ments,and chinese traditional herbs,for onemonth. Group B was sereved as control.In addi-tion,group C of 20 workers was served as anunexposed control group.All workers were ob-served for one month during exposure to flu-onide,The results showed that the concentra-tions of urinary fluoride and tetrafluoroboratein workers of group A,as compared with twocontrol groups,were significantly increased,thealkaline phosphatase activity reduced,the con-tent of zinc,copperiron in serum increased,theability of red cell immune abherence was en-hanced.It suggested that jiefurui might have aneffect of preventing fluoride damage.

关 键 词：拮氟锐 抗氟作用 药理学 

分 类 号：R969[医药卫生—药理学]