大鼠矽肺BALF中DPPC与Ⅱ型细胞改变关系的研究  

Studies on DPPC in the BALF of Experimental Silicotic Rats

作　　者：杨青[1] 

机构地区：[1]华西医科大学公共卫生学院

出　　处：《中国工业医学杂志》1995年第6期324-325,350,共3页Chinese Journal of Industrial Medicine

摘　　要：本文采用非暴露式气管注入法对大鼠一次染尘５０ｍｇ，染尘后１５、４５、９０、１８０和２７０天分批剖检，测定支气管肺泡灌洗液（简称ＢＡＬＦ）中二棕榈酰卵磷脂（简称ＤＰＰＣ）含量，同时对肺组织标本进行扫描电镜观察。结果表明在实验早期ＤＰＰＣ含量就达高峰，随染尘时间延长，ＤＰＰＣ含量逐渐下降。ＤＰＰＣ含量变化与扫描电镜下Ⅱ型上皮细胞的数量和功能改变相关。at were injected with 50mg of silica in-tratracheally.The contents of dipalmitoyph-opatidylcholine(DPPC)of the broncho arcolarlarvage fluid(BALF)were defccted on 15,45,90,180 and 270 days after dosing.The lungtissues of silicotic rats were examined underscanning electromicrcscopy. The results showthat the DPPC peaks at early stage and decl-ines along with the experimental duration.There is a condation the DPPC lev-els and the changes of amount and function of the tape 2 areolar epithelium under scammingelectromicroscopy.

关 键 词：职业危害 矽肺 二棕榈酰卵磷脂 上皮细胞 

分 类 号：R135.2[医药卫生—劳动卫生]