新型络合剂MeOBGDTC对尿镉及微量元素排泄的影响  

Effect of MeOBGDTC on Excretion of Cadmium and Endogenous Metals

作　　者：张久松[1] 李革新[1] 丁桂英[1] 

机构地区：[1]中国医科大学预防医学系

出　　处：《中国公共卫生学报》1995年第3期189-190,共2页

摘　　要：以依地酸二钠钙（Ｃａ—ＥＤＴＡ）为对照，观察了４—甲氧苄基Ｄ—葡糖胺—Ｎ—二硫代羧酸钠（ＭｅＯＢＧＤＴＣ）对染镉大鼠尿镉及尿锌、铜、铁、锰等微量元素的促排作用。给大鼠腹腔注射４．４４８μｍｏｌＣｄ（２＋）ｋｇ（－１）日（－１）的氯化镉，共４周。然后分别投以８８９．６００μｍｏｌｋｇ（－１）日（－１）的Ｃａ—ＥＤＴＡ和ＭｅＯＢＧＤＴＣ，共５次。结果表明：Ｃａ—ＥＤＴＡ和ＭｅＯＢＧＤＴＣ均能显著增加大鼠的尿镉水平，并可持续至第５给药日，分别达单纯染镉组的１．４６～３．４５倍和１．４０～３．３３倍；Ｃａ－ＥＤＴＡ还能明显增加大鼠尿锌、锰及铁的排泄，而ＭｅＯＢＧＤＴＣ对此则无明显影响。The effect of sodium N-4-methoxybenxyl D-glucamine-N-carbolithioate (MeOBGDTC) on the urinary elimination of cadmium and several endogenous metals was determined in rats in contrast to calcium disodium ethylenediamine tetraacetate (Ca-EDTA). After exposed to cadmium chloride(4.448μmol Cd(2+) /Kg /day. 4 weeks, i. p). rats were given MeOBGDTC and Ca-EDTA(889. 600μmol/Kg/day, 5 times.i. p). The results showed that both Ca-EDTA and MeOBGDTC significantly increased the urinary excretion of cadmium .and continued to the fifth day of treatment .and was more 0. 46-2. 45 times,0. 40～2. 33 times than the group exposed to cadmium singly. Ca-EDTA also significantly increased the urinary excretion of zinc, iron and manganese, but MeOBGDTC had no effect on the urinary elimination of any of metal studied.

关 键 词：MeOBGDTC 尿 镉 微量元素 络合剂 依地酸二钠钙 

分 类 号：R965.2[医药卫生—药理学]