二十碳五烯酸抗拴作用的实验研究  

EXPERIMENTAL STUDIES ON ANTITHROMBOSIS OF EICOSAPENTAENOIC ACID

作　　者：尚雪原[1] 张世玲[1] 焦波[1] 鲁凤友[1] 程艳娜[1] 袁玮[2] 

机构地区：[1]山东医科大学药学系药理教研室,济南250002 [2]基础部药理教研室

出　　处：《中国海洋药物》1995年第4期6-9,共4页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金资助项目

摘　　要：对二十碳五烯酸(EPA)的抗栓作用及其机制进行了研究。结果表明,EPA在体内、体外均有明显抗栓作用,并能增强纤溶活力,缩短优球蛋白溶解时间,抑制花生四烯酸和胶原诱导的大鼠血小板聚集。放射免疫测定证明,EPA能降低小鼠血浆血拴素B_2(TXB_2)含量,提高6-酮前列腺素F_(1α)与TXB_2的比值。The effects of eicosapentaenoic acid (EPA) on experimental thrombosis and its mechanism were studied. The results showed that eicosapentaenoic acid had a significant antithrombolic effect both in vivo and in vitro . EPA also had a fibrinolytic activity and can shorten euglobulin lysis time. Our studies also showed that EPA can inhibit platelet aggregation in rats. The plasma concentration of 6-keto-PGF1a and TXB2 was measured by radioimmunoassay. The results showed that EPA can reduce the contents of TXB2 and raise 6-keto-PGF1a/TXB2 ratio.

关 键 词：二十碳五烯酸 抗血栓 血小板聚集 

分 类 号：R973.2[医药卫生—药品]