输精管绝育术对实验性家兔动脉粥样硬化症的影响  

Influence of Vasectomy to the Experimen-tal Rabbit Atherosclerosis,

作　　者：刘世沧[1] 何才偆[2] 

机构地区：[1]华西医科大学法医系病理教研室,成都610041 [2]四川省计划生育科学研究所

出　　处：《中国计划生育学杂志》1995年第3期139-141,共3页Chinese Journal of Family Planning

基　　金：联合国人口基金会资助项目

摘　　要：报告家兔输精管绝育术后的免疫反应对实验性动脉粥样硬化的影响。日本大耳白兔20只分为4组,每组5只,A、B组作输精管绝育术,B、C组在绝育术后20周用高脂饮食喂养25周,D组为空白对照,整个实验程期共为10月左右(45周)。各组同时结束实验,病理组织学检查,可见绝育组动物睾丸和附睾局部精子淤滞和破入间质引起的反应。在高脂饮食组中:输精管绝育组有3只,未绝育组有2只,肉眼可见主动脉和颈动脉处有粥样化斑形成,镜检10只动物皆有不同程度的类脂沉着,两组比较无明显差异。本动物实验证明输精管绝育术不能促进动脉粥样硬化的发展。Twenty Japanese white rabbits were devided into four groups. There are five animals in each group. Group 1 and 2 were used for vasectomy. Twenty weeks after post-vasectomy,group 2 and 3 began to be fed high-fat diet though twenty-five weeks duration. Group 4 was used for control. Rabbits of each group were killed in the same time. Pathologic investigations showed that sperm stasis in epididymis and intestitial . lamphocytic infiltrations and sperm-granulomas were found in rabbits of vasectomised groups. There were three va-sectomised and two sham-vasectomised rabbits showed macroatherosclerotic lesions in aorta and carotid. Microscopically, all of the ten rabbits showed lipoid deposition and active phagocytosis. To compare group 2 with group 3, there are no apparent difference between the two groups. The priliminary result of this study shows that the sperm immunity didn' t influence the formation of atherosclerosis.

关 键 词：输精管绝育术 动脉粥样硬化 输精管结扎术 

分 类 号：R699.8[医药卫生—泌尿科学] R543.5[医药卫生—外科学]