左旋吡喹酮与右旋吡喹酮治疗对体内日本血吸虫皮层损害的扫描电镜观察(英文)  

SCANNING ELECTRON MICROSCOPE OBSERVATION ON TEGUMENTAL ALTERATION OF SCHISTOSOMA JAPONICUM INDUCED BY LEVO AND DEXTRO PRAZIQUANTEL

作　　者：肖树华[1,2] 沈炳贵[1,2] 

机构地区：[1]中国预防医学科学院寄生虫病研究所 [2]世界卫生组织疟疾,血吸虫病和丝虫病合作中心

出　　处：《中国寄生虫学与寄生虫病杂志》1995年第1期46-50,共5页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：感染日本血吸虫３５ｄ的小鼠用左旋吡喹酮（Ｌ－Ｐｒａ）１５０ｍｇ·ｋｇ－１，或右旋吡喹酮（Ｄ－Ｐｒａ）１５０、６００ｍｇ·ｋｇ－１１次灌胃治疗，在给药后的１５ｍｉｎ，１、２、４、８、２４ｈ分别解剖取虫，以扫描电镜观察血吸虫的皮层变化。结果，发现，Ｌ－Ｐｒａ１５０ｍｇ·ｋｇ－１对血吸虫可引起明显和广泛的损害，包括皮层的严重肿胀、融合、糜烂和剥落，并伴有宿主白细胞的粘附；盘状感觉器官亦示有明显的肿胀、变形和破溃。用Ｄ－Ｐｒａ１５０ｍｇ·ｋｇ－１治疗的血吸虫皮层损害轻微。如剂量增至６００ｍｇ·ｋｇ－１，虫的皮层损害与Ｌ－Ｐｒａ１５０ｍｇ·ｋｇ－１引起的相似，但程度较轻。结果认为，吡喹酮的２种旋光对映体对血吸虫的药理作用虽极为相似，但右旋吡喹酮的作用较左旋吡喹酮的为差。When mice infected with Schistosoma japonicum for 35 d were treated ig with levo praziquantel (L Pra) 150 mg·kg -1 or dextro praziquantel (D Pra) 150-600 mg·kg -1 ,the alterations of the worm tegument were examined by scanning electron microscopy within 1-24 h after administration. The results showed that L Pra induced apparent and extensive damage on the worm surface including severe swelling, fusion, erosion and peeling of tegument accompanied by attachment of the host leukocytes. The discoid like sensory structures usually showed swelling, deformation and collapse. With D Pra 150 mg·kg -1 , only slight damage of tegument was seen. When the dose was increased to 600 mg·kg -1 ,the damage of worm tegument was similar to that induced by L Pra 150 mg·kg -1 but the intensity of the damage was slighter as compared to that induced by L Pra. The results suggested that the actions of the 2 optical enantiomers of praziquantel were different in quantity but not in quality.

关 键 词：日本血吸虫 扫描电镜 左旋吡喹酮 右旋吡喹酮 

分 类 号：R978.6[医药卫生—药品]