血吸虫病人吡喹酮治疗后血清虫卵抗体十年追踪观察  

A TEN YEAR FOLLOW UP OBSERVATION ON SERUM ANTIBODY LEVEL IN SCHISTOSOMIASIS PATIENTS TREATED WITH PRAZIQUANTEL

作　　者：徐尚敖[1,2] 夏章武[1,2] 占福初 徐兰英 

机构地区：[1]浙江省江山市人民医院 [2]浙江省常山县地方病防治站

出　　处：《中国寄生虫学与寄生虫病杂志》1995年第2期142-144,共3页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：本文应用酶联免疫吸附试验（ＥＬＩＳＡ），对１２２例经吡喹酮治疗后血吸虫病患者的血清虫卵抗体水平进行了１０年追踪观察。结果表明，血清虫卵抗体的效价逐年递减，治疗前ＥＬＩＳＡ反应滴度≥１∶８００，占８７．７％，治疗后１年占２１．２％，２年占１％，２年后均＜１∶８００。ＥＬＩＳＡ转阴率在治后１—５年及第１０年分别为５３．２％、７９．８％、８２．３％、９５．７％、９５．９％及９７％，治后４年ＥＬＩＳＡ阳性率与正常人出现的假阳性率比较，无显著性差异（Ｐ＜０．０５）．表明血吸虫病人经治疗后，血清中残留虫卵抗体水平需４年才能显著下降，因此治后４年ＥＬＩＳＡ阳性滴度≥１∶４００，可作为未治愈病人的辅助诊断指标。The detection of the serum antibody in 122 schistosomiasis patients, using enzyme linked immunosorbent assay (ELISA), had been carried out from 1980 1989. The results showed that the potency of serum antibody was on an annual progressive decrease. Before treatment, the rate of ELISA reactive titre above 1∶800 was 87.7%, while after treatment it was 21.2% in the first year and 1% in the second year and even lower in the following years. The antibody negative conversion rate with ELISA from the first to the fifth year after praziquantel treatment ranged from 53.2% 95.9%, whereas it was 97.0% in the tenth year. No significant difference was found between the ELISA positive rate in patients treated after 4 years and the false positive rate in normol persons ( P >0.05). The data demonstrate that it took four years after therapy for the noticeable reduction of the residual serum antibody level in patients, and that the ELISA positive reaction titre≥1∶400 in patients 4 years after treatment might be used as complementary diagnostic index for those uncured patients.

关 键 词：吡喹酮 治疗 血吸虫病 虫卵抗体 酶联免疫吸附法 

分 类 号：R532.210.5[医药卫生—内科学]