头孢羟氨苄的临床药物动力学研究  

Clinical pharmacokinetic study on cefadroxil

作　　者：张菁[1] 曹忆堇[1] 张婴元[1] 

机构地区：[1]上海医科大学华山医院抗生素研究所

出　　处：《中国抗生素杂志》1995年第1期45-47,共3页Chinese Journal of Antibiotics

摘　　要：健康志愿者８名单剂空腹口服头孢羟氨苄片剂ｌｇ后，其血药峰浓度（Ｃ（ｍａｘ））为３１．５７ｍｇ／Ｌ，达峰时间（Ｔ（ｍａｘ））为１．５４ｈ，消除半衰期（Ｔ（１／２）Ｋｅ）为１．３９ｈ，药时曲线下面积（ＡＵＣ）为１０８．５９ｈ·ｍｇ／Ｌ与头孢羟氨苄原粉相比，比率为１．０７１。口服该药主要自肾排出，２４ｈ尿排出率为药量的９０％左右，根据药动学参数，提出治疗细菌感染的给药方案。Clinical pharmacokinetic study on cefadroxil was carried out in 8 healthyvolunteers after oral administration of lg. Mean C(max),T(max) and T(1/2) Ke were 31.57mg/L,1.54 and 1.39h respectively. The AUC of cefadroxil tablet was 108.59h·mg/L. Comparedwith that of cefadroxit powder, the ratio was 1.071.Difference of the above parameters was not statistically significant.Cefadroxil was mainly excreted through kidney. The urinary recovery rate of drug over 24h was above 90%. Based on the pharmacokinetic parameters,a therapeutic regimen is suggested for the treatment of bacterial in fections.

关 键 词：药物动力学 头孢羟氨苄 药理学 

分 类 号：R978.11[医药卫生—药品]