培氟沙星治疗821例细菌感染临床评价  

Clinical evaluation of pefloxacin in the treatment of 821cases of bacterial infections

作　　者：李为[1] 李立津[1] 刘德孟 胡文芝[1] 王燕[1] 王玉莲 胡顺先 王每先 乔地山 王化文 保国章 李淑英 董春元 

机构地区：[1]天津医科大学第二附属医院,天津医学院第一附属医院,天津市第四人民医院,辽宁省人民医院,白求恩医科大学附属医院,内蒙古医学附属医院,内蒙古蒙医医院,解放军253医院,哲里木盟医院,内蒙古通辽制药厂

出　　处：《中国抗生素杂志》1995年第2期144-147,共4页Chinese Journal of Antibiotics

摘　　要：培氟沙星（ＰＦＬｘ）８２１例临床观察，不良反应发生率为１１．１％，主要表现为消化道反应，其次为皮疹，多数病人程度不重，可以耐受。０．２、０．３ｇ每日２次服用，可明显降低不良反应发生率及严重程度。本实验扩大了Ⅱ期临床验证的病种和年龄，痊愈率为６５．７％，有效率为９２．５％。９７例老年及３１例肝肾功能不全病人的临床观察证实，ＰＦＬＸ对以上病人安全可靠。因观察时间不够长，而ＰＦＬＸ经肝代谢，对有明显肝功能不全者，慎用为宜。The clinical efficacy of 821 cases of various bacterial infections treatedwith pefloxacin(PFLX)was reported.Adverse drug reaction rate was 1 1.1%. Adverseeffects included gastrointestinal disorders predominantly.and rash secondly. Most reactionswere lnild and well tolerated. Treating patients with one 0. 2 or 0.3g oral dose twice a daycould obviOusly reduce the rates and severity of adverse reactions. This clinical study extendranges of bacterial infections and ages. The total cure rate and effective rate was 65.7%and92.5%respectively. The investigation of 97 cases of elderly and 31 cases of hepatic or renalinsufficiency patients confirmed that PFLX was safety for these subjects. Because theduration of observation was short and the PFLX was chiefly metabolized through liver. patients with evident hepatic dysfunction should use PFLX carefully.

关 键 词：培氟沙星 细菌感染 临床评价 药物副作用 

分 类 号：R978.19[医药卫生—药品] R515.05[医药卫生—药学]