6种抗生素对临床分离406株革兰氏阴性杆菌体外抗菌活性比较  

In vitro comparative activity of 6 antibiotics against 406 Gram-negative isolates

作　　者：曲晓华[1] 李国忠[1] 李真[1] 安伟 张雅莲[1] 甄然[1] 

机构地区：[1]北京积水潭医院

出　　处：《中国抗生素杂志》1995年第5期357-361,共5页Chinese Journal of Antibiotics

摘　　要：１９９３年２月至１９９４年２月，从我院住院患者分离４０６株革兰氏阴性杆菌。细菌鉴定、ＭＩＣ测定由本院微生物实验室Ｖｉｔｅｋ－全自动微生物分析系统完成。统计４种第三代头孢菌素、亚胺培南、环丙沙星的ＭＩＣ５０、ＭＩＣ９０、ＭＩＣｍｏｄｅ、ＭＩＣｒａｎｇｃ，并比较其体外抗菌活性，结果表明：亚胺培南对分离的４０６株革兰氏阴性杆菌显示出强大的体外抗菌活性，头孢他啶、环丙沙星对绿脓假单胞菌依然保持了较强的体外抗菌活性。除亚胺培南外，其余５种抗生素对临床分离革兰氏阴性杆菌体外抗菌活性均有不同程度的降低。This paper reported the in vitro comparative activity of 6 antibioticsagainst 406 Gram-negative bacteria isolated from hospitalized patients in our hospital fromFeb.1993 to Feb.1994.Those were、cefoperazone,cefotaxime, ceftriaxone, ceftazidime,imipenem and ciprofloxacin. Isolates identification and antibiotics MICs determination wereundertaken by Vitek-AMS. Results demonstrated that imipenem Was the most active againstaIl isolates. Ceftazidime and ciprofloxacin express stronger actlvity against Psudomonasaeruginosa than others.In vitro activity against all clinical isolates are reduced respectively in5 antibiotics except imipenem than non-clinical ones.

关 键 词：头孢哌酮 亚氨培南 革兰氏阴性杆菌 抗菌活性 

分 类 号：R978.1[医药卫生—药品] R978.69[医药卫生—药学]