大鼠肌注抗生素89－07、阿米卡星和庆大霉素肾毒作用的比较  

Comparative studies on nephrotoxicity of antibiotic 89-07,gentamicin and amikacin in rats

作　　者：李培忠[1] 孙永立[1] 郑德琪[1] 于文梅 沈菊英 翟文生[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《中国抗生素杂志》1995年第6期459-459,470,共2页Chinese Journal of Antibiotics

摘　　要：抗生素８９－０７、庆大霉素、阿米卡星按每天５０、１００、１５０ｍｇ／ｋｇ，ｉｍ给予大鼠。分别于给药后５、１０、１５天处死动物，取样作肾功能和肾脏光镜形态学检查，比较评价了３种氨基糖苷类抗生素的肾脏毒性，ｉｍ庆大霉素１００ｍｇ／（ｋｇ·ｄ）以上剂量的动物，给药后７天就出现死亡，５０ｍｇ组随给药时间的延长，肾功能异常的指标逐渐增多，肾小管上皮细胞也由个别散在性的坏死发展到大片状和广泛性的严重坏死。抗生素８９－０７和阿米卡星５０ｍｇ组，仅见个别肾功能指标异常，肾小管上皮细胞仅见混浊肿胀等变性，即使是１００ｍｇ组的肾小管上皮细胞坏死的程度也没有庆大霉素５０ｍｇ组严重。上述结果表明，抗生素８９—０７的肾毒作用明显比庆大霉素轻。The relative nephrotoxicity of antibiotic 89-07,gentamicin(GM) andamikacin(AMK)were compared at the doses of 50, 100 and 150mg/(kg· d)in for 5,10,15days。 Death occured at the dose higher than 100mg/l(kg·d)in 7 days after injecting GM。No death occured in the animals receiving antibiotic 89-07 and AMK。 Function abnormalityin the kidney were observed at the dose of 100mg/(kg·d)in 10 days following dose forantibiotic 89-07 and that of 50mg/(kg· d) in 5 days following dose for antibiotic 89-07 andthat of 50 mg/(kg·d)in 5 days followiiig dose for GM, The main changes observed inhistopathology were degeneration and necrosis of the tubules epithelicum in a dose and time related manner, h0wever, antibiotic 89-07 and AMK aresignificantly less changes at all doses than GM, The data indicate that in the rat givenantibiotic 89-07 is distinctly less nephrotoxicity than GM。

关 键 词：抗生素 89-07 阿米卡星 庆大霉素 肾毒性 

分 类 号：R978.12[医药卫生—药品]