抗生素89－07的细胞染色体畸变  

Forward mutation studies of antibiotic 89-07 in Chinese hamster ovarv cell

作　　者：张慧娟[1] 朱玉珍[1] 

机构地区：[1]上海医药工业研究院

出　　处：《中国抗生素杂志》1995年第6期464-466,共3页Chinese Journal of Antibiotics

摘　　要：抗生素８９－０７的细胞染色体畸变张慧娟，朱玉珍（上海医药工业研究院，上海２００４３７）用中国仓鼠肺细胞（ＣＨＬ）染色体畸变试验评价抗生素８９－０７的诱变能力。实验包括加入和不加代谢活化系统两部分，抗生素８９－０７浓度为３、６、１２ｍｇ／ｍｌ，以环磷酰...The mutagenicity of antibiotic 89-07 was assayed for forward mutation inChinese hamster ovary cell. Antibiotic 89-07 was not mutagenic at the concentrations within20～80 mg/ml either with or without metabolic activation system。Results showed that themutation frequency of antibiotic 89-07 was within the spontaneous range 0～20/106 cells.

关 键 词：抗生素 89-07 正向突变 卵巢细胞 

分 类 号：R978.12[医药卫生—药品]