藏、汉族健康志愿者氨茶碱的药代动力学的研究  

THE STUDY OF PHARMACOKINETICS OF AMINOPHYLLINE IN TIBETAN AND HAN HEALTHY VOLUNTEERS

作　　者：李成义[1] 孙芳云[1] 贺平[1] 刘桂贤[1] 张琰[1] 缪海均[1] 刘志红[1] 杨阳[1] 胡锡佑 

机构地区：[1]西安第四军医大学唐都医院临床药理室,西藏民族学院医疗系药理教研室

出　　处：《中国临床药理学杂志》1995年第1期45-47,共3页The Chinese Journal of Clinical Pharmacology

基　　金：西藏科委资助

摘　　要：采取高效液相色谱法，测定唾液氨茶碱浓度，研究了藏、汉族健康志愿者氨茶碱半衰期（Ｔ１／２）和消除速率常数（Ｋ）的差异；以及高原区藏族人氨茶碱的Ｔ１／２和Ｋ。１４例藏族人氨茶碱Ｔ１／２为８．１２±２．１０ｈ，Ｋ为０．０８９８±０．０３１（ｈ￣－１）；１３例汉族人氨茶碱Ｔ１／２为８．７１±２．４４ｈ，Ｋ为０．０８５８±０．０２７７（ｈ￣－１）。９例高原区藏族人氨茶碱Ｔ１／２为９．５０±３．０９（ｈ）￣－１，Ｋ为０．０８２９±０．０３８６（ｈ￣－１）。实验结果表明，藏、汉两民族氨茶碱Ｔ１／２及Ｋ无明显差异，居住高原地区不影响氨茶碱代谢。The concentration of aminophylline in saliva was measured by a HPLC method in 14 Tibetan and 13 Han healthy volunteers to study the difference in disposition of the drug between the two ethnic groups, T1/2 was 8.12±2.10 h in Tibetan and 8.71±2.44h in Han (P>0.05); K was 0.0898±0.0310 (h-1) in Tibetan and 0.0858 ±0.0277 (h-1) in Han (P>0.05). In addition, the pharmacokinetic parameters of aminophylline was calculated from saliva in 9 Tibetan living in Xizang highland; their meanir mean half-life was 9.50±3.09 h and elimination velocity constant was 0.0829±0.0386 (h-1). The results showed that the disposition of aminophylline between Tibetan and Han healthy volunteers had no difference and living in the highland area did not affect the metabolism of the drug.

关 键 词：氨茶碱 药代动力学 汉族 藏族 

分 类 号：R974.3[医药卫生—药品]