思密达治疗腹泻患儿肠道微生态学观察  

INTESTINAL MICROECOLOGICAL OBSERVATION OF SMECTITE IN THE TREATMENT OF DIARRHEA IN CHILDREN

作　　者：王俊侠[1] 方鹤松[1] 

机构地区：[1]首都儿科研究所

出　　处：《中国临床药理学杂志》1995年第3期134-137,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：本文用常规细菌学和细菌分子生物学等技术对５５例腹泻患儿治疗前后肠道菌群的变化进行观察，对四种细菌：双歧杆菌、拟杆菌、肠球菌、肠杆菌进行检测。结果表明：腹泻时全部患儿肠道菌群发生明显变化，厌氧菌群中的双岐杆菌、拟杆菌的细菌数量明显减少，而需氧菌却相对增加，厌氧菌与需氧菌之比由１０００：１下降到１：１。用思密达治疗５ｄ后患儿失调的肠道菌群趋向正常，厌氧菌与需氧菌之比上升为１００：１，其中双岐杆菌数较治疗前增加１５８倍，而其它３种菌无明显变化。而对照组失调的肠道菌群未发生改变。由此可见思密达其扶植肠道中厌氧菌，提高双歧杆菌在肠道中的水平和调整肠道菌群紊乱也是治疗腹泻的作用机理之一。The normal flora in human's intestine is a very important in microecological system.Among them,anaerobe is 99% absolute dominance and the majority of the them is bifidobacteria(95%).In this study,the changes of intestinal flora of 41 cases were observed, among which 30 cases belonged to testing group treated with smectite and 25 cases to control group with persin mixture(MP)before and after treatment by the technology of regular bacteriology and bacterial molecular biology to detect the change in 4 kinds of bacteria(two of them were anaerobe which were bifidobacteria and bacteroid, other two were aerobe which were enterococcus and enterobacteria) stood for alteration of intestinal flora. The result showed that before treatment,the intestinal flora of all diarrheal children have changed obviously. Among anaerobe, the populations of bifidobacteria and bacteroid decreased significantly. whereas the number of aerobe relatively increased. The ratio of anaerobe to aerobe decreased from 1000:1 to 1:1.As a result,the patients'inrestinal flora altered and disordered. After five days of treatment with smectite(5-day cure rate is 96.67%).the alteration of intestinal flora recovered at some extent,the populations of Bifidobacteria increased 158 folds.Whereas there was no significant change in number of other 3 kinds bacteria.However,in control group treated with MP(5-day cure rate is 68.00%),the state of flora imbalance hadn't been improved.In the followed two week's trace investigation,we didn't find any case of smectite group to recur,but 11.76% cases in control group recurred. The results indicated that of important mechanisms of smectite is that it enchances the growth of anaerobe in intestine and inereases the level of intestinal bifidobacteria so that it can adjust the alteration of intestinal flora and reinforce the barrier action of microorgnisms, beside it can adhere to pathogens and excrete it, reinforce intestinal mucosal barrier and help regeneration of epithelimu.In conclusion, smectite has significant efficien

关 键 词：思密达 肠道菌群 微生态学 儿童 腹泻 

分 类 号：R975[医药卫生—药品]