静脉注射米力农对充血性心力衰竭患者的血流动力学作用  

HEMODYNAMIC EFFECTS OF INTRAVENOUS MILRINONE IN PATIENTS WITH CONGESTIVE HEART FAILURE

作　　者：单江[1] 张雪华[1] 宋小燕[1] 熊伟[1] 徐耕[1] 葛宏余[1] 江力勤[1] 

机构地区：[1]浙江医科大学附二院心内科,浙江宁海县人民医院内科,浙江嘉兴市第一人民医院监护室

出　　处：《中国临床药理学杂志》1995年第4期224-228,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：本试验采用有创性血流动力学测定方法评价静脉注射米力农对充血性心力衰竭患者的血流动力学的影响。８例慢性充血性心力衰竭患者，在注入米力农负荷量５０μｇ／ｋｇ后，心输出量和心脏指数分别较前升高了４６．３％和４８．５％，肺毛细血管嵌压较前下降了４３．８％，体循环阻力和肺循环阻力分别较前下降了３９．４％和４８．０％；在４ｈ的维持用药期间，血流动力学的改善持续存在。未见明显不良反应。结果表明短期静脉注射米力农能迅速、有效、安全地改善充血性心力衰竭患者的血流动力学。To evaluate the hemodynamic effects of intravenous milrinone. 8 patients with chronic heart failure were studied in this test.Milrinone was given 50 μg/kg as a loading injection followed by an infusion with 0.5 μg· kg￣(-1)·min￣(-1) for 4 hours.It was found that after infusion of the loading dose, cardiac index increased from 2.27 to 3.371/m2/min(P<0.01), pulmonary capillary wedge pressure decreased from kPa 2.28 to 1.28(17.13 to 9.63 mmHg)(P<0.01),systemic vascular resistance decreased from 1959.04 to 1187.87 dynes,sec/cm￣5(P<0.01), and pulmonary vascular resistance decreased from 206.39 to 107.42 dynes.sec/cm￣5(P<0,01). The early improvement in hemodynamics was sustained throughout the 4-hour infusion period. Development of tolerance was not observed, nor were any clinical symptomatic side effects. The results suggest that short-term infusion of milrinone is an effective and safe medication to bring rapid and prolonged improvement in hemodynamics in patients with chronic heart failure.

关 键 词：充血性心力衰竭 心力衰竭 米力农 血流动力学 

分 类 号：R541.610.5[医药卫生—心血管疾病] R972.4[医药卫生—内科学]