北芪对老龄机体细胞因子产生影响的实验研究  

EFFECT OF AMB ON THE CYTOKINE PRODUCTION OF AGEDSUBJECTS

作　　者：王文余[1] 常金兰[1] 高静[1] 田景先[1] 赵育莹[1] 

机构地区：[1]哈尔滨医科大学免疫学教研室

出　　处：《中国免疫学杂志》1995年第3期167-169,共3页Chinese Journal of Immunology

摘　　要：本文以１５月龄昆明鼠和６０～７２岁老龄人为对象，采用生物学活性检测法观察了北芪对老龄鼠脾细胞受ＣｏｎＡ刺激后产生ＩＬ－２，ＴＮＦ及ＩＦＮ－γ水平的影响，采用ＥＬＩＳＡ双抗体夹心法检测了老龄鼠脾细胞上清中ｓＩＬ－２Ｒ含量。实验结果证明老龄机体ＩＬ－２，ＴＮＦ和ＩＦＮ－γ分泌功能下降，ｓＩＬ－２Ｒ水平增高。服用北芪后明显地提高了老龄机体的ＩＬ－２，ＴＮＦ和ｒＩＦ－γ水平，降低了ｓＩＬ－２Ｒ水平，进而证明北芪是一种良好的免疫增强剂，能增强老龄机体抗肿瘤、抗感染，预防自身免疫病的发生及抗衰老等作用。his paper reports that the effect of AMB on the cytokines in aging mice and elderly sub-jects. The results indicated that the cytokines of elderly organism were markedly lower thanthose of control group,but after treatment with AMB, the immune function vvas significantlyincreased. The IL-2 . TNF and IFN-γ in the culture fluid of spleen cells from aging mice wasdetermined with bioassavs method and the sIL-2R was examined with ELISA. The resultsshowed that the levels of IL-2、TNF and IFN-γ were more higher than those of control group inafter treatment of AMB, but the level of sIL-2R was decreased significantly. Thus the authorbelived that AMB may play a regulatory role on immunological function and against infecti on,tumor, autoimmune disease.

关 键 词：北芪 细胞因子 老化 免疫药理学 

分 类 号：R282.710.3[医药卫生—中药学] R967[医药卫生—中医学]