刺五加对肺纤维化BALF中IL－6抑制作用的研究  

THE STUDY ON THE INHIBITED EFFECT OF ACANTHOPNANACISON THE IL-6 SECRETED IN BALF OF RAT PULMONARY FI-BROUS

作　　者：张捷[1] 安继红[1] 张伟[1] 赫国志[1] 孙庆[1] 王晓东[1] 

机构地区：[1]白求恩医科大学第二临床学院呼吸内科,吉林省计划生育研究所,白求恩医大基础部电镜教研室

出　　处：《中国免疫学杂志》1995年第5期300-302,共3页Chinese Journal of Immunology

基　　金：吉林省卫生厅资助

摘　　要：在用石棉灌肺制成大鼠支气管肺纤维化模型基础上，应用刺五加注射液进行体内实验治疗。测定了治疗及非治疗组大鼠支气管肺泡灌洗液中单个核细胞自分泌白细胞介素６（ＩＬ－６）水平，经统计学处理两组差异显著（Ｐ＜０．０１）。说明了刺五加对ＩＬ－６的分泌有抑制作用。可能对细胞因子网络紊乱有调节作用，为临床应用刺五加治疗肺纤维化提供了实验依据。he pulmonary fibrous model of rat was produced by asbestos.ON the basis of the medel,the test treatment in rat body is made by injectiiig acanthopanacis. The secretion state of IL-6 inBALF of rats was examined in treatment grotip and control one. The result shows significantdifference( P <0. 01).Above this fact indicates that IL-6 secretion have been depressed andprohapes cytokine net is regulated by acanthopanacis.The experiment offers a base for acan-thopanacis to treat the pulmonary fibrotis.

关 键 词：肺纤维化 白细胞介素6 肺泡灌洗液 刺五加 药理 

分 类 号：R282.710.3[医药卫生—中药学] R967[医药卫生—中医学]