地方性慢性砷中毒皮损内郎格罕细胞的研究  

A Study on Langerhaus Cell in Skin Lesions or patients with Endemic Chronic Arsenism

作　　者：多兰[1] 黄月珍[1] 钱戌春[1] 

机构地区：[1]新疆医学院第一附属医院皮肤科

出　　处：《中国皮肤性病学杂志》1995年第1期14-15,共2页The Chinese Journal of Dermatovenereology

摘　　要：采用单克隆抗体Ｌｅｕ６间接免疫酶标法对新疆车排子地区地方性慢性砷中毒（ＥＣＡ）２５例３０份皮损内郎格罕细胞（ＬＣ）进行研究，发现２５份非肿瘤性角化症病变区表皮的角质层增厚，表皮内ＬＣ数增加，３份色素异常性皮损的表皮色素颗粒减少或消失区内ＬＣ数较多。２份恶性角化症，且份为鲍温病，其病变区内ＬＣ数目较多，而另１份鳞癌的癌巢中未见ＬＣ。认为砷角化症及色素异常的发生、发展及皮肤癌变的可能与皮肤ＬＣ有着密切的关系。The result of a study on Langerhans cell (LC) inskin lesions of 30 specimens from 25 patients with endemic chronic arsenism(ECA) in Che Pai Zi area Xinjiang was reported. The monoclonal antibody Leu6 indirect immunoenzyme technique was used. In 25 nontumor keratosis both the thickness of horny layer of epidermis in lesion area and epidermal LC were increased.More LCs were found in the epidermal area where pigmented particles decreased or disappeared in three dyspigmentend skin lesions. In two specimens of malignantkeratosis,more LCs were seen in the epidermal lesionof one Bowen's disease,and no LC was seen in the cancer nest of one squamous carcimoma. The authors regard that pathogenesis and development of arsenic keratosis and dyspigmentation and malignant change ofskin might have a close relation to the LC in the skin.

关 键 词：砷中毒 郎格罕细胞 地方性疾病 

分 类 号：R599.9[医药卫生—内科学]