麻风病人外周血中性粒细胞和淋巴细胞产生氧自由基功能的研究  

Function of Superoxide Radical(·O_-￣2) Produced by Neutrophil and Lymphocyte From Periheral Blood of Leprosy Patients

作　　者：黄林邦[1] 张志渊[1] 

机构地区：[1]赣南医学院皮肤病理研究室

出　　处：《中国皮肤性病学杂志》1995年第1期18-19,共2页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金

摘　　要：用化学发光法测定麻风病人外周血中性粒细胞（ＰＭＮ）和淋巴细胞（ＬＣ）受刺激后释放氧自由基，引发化学发光的情况。与正常人比较，ＬＬ、ＢＬ活动期病人的ＰＭＮ发光值均弱（Ｐ＜０．０５）；ＴＴ、ＢＴ活动期病人的ＰＭＮ发光值稍差，但其ＬＣ发光值增高（Ｐ＜０．０５）；各型麻风愈复期病人的ＰＭＮ和ＬＣ发光值与正常人近似。说明活动期病人ＰＭＮ产生氧自由基功能低下，是麻风发病的主要因素。With a luminol-dependent chemiluminescence assay, assessed the function of. O produced by neutrophil (PMN ) and lymphocyte (LC) from peripheralblood of leprosy patients,after the cell to be stimulatedrespectively by OZ or Con. A. The results showed thatthe chemiluminescence of PMN and LC from the activepatients of LL. BL. (group A) was the weakest amongall groups (P< 0. 05) ; the chemiluminescence of PMNfrom the active patients of TT. BT. (group C ) wasslightly decreased, however, the hyperfunction ofchemiluminescene appeared in the LC from group C(P<0.01),as compared with that of normal subjects. Thechemiluminescence of PMN and LC from the cured patients of LL. BT. (group B) and TT. BT(group D) wassimilar to that of normal subjects (P > 0. 05). It wasproved that hypofunction of PMN from the active patients is one of important factors in leprosy pathogenesis.

关 键 词：游离基类 发光 嗜中性粒细胞 淋巴细胞 麻风 

分 类 号：R755[医药卫生—皮肤病学与性病学]