幽门螺杆菌耐药性测定及其机制的初步探讨  

A Preliminary Study on the Drug-Resistance Mechanism of Helicobacter pylori

作　　者：佘菲菲[1] 刘延深 苏东辉[1] 俞树高[1] 郑秀芬[1] 陈月秀[1] 陈红绉[2] 周琳瑛[3] 

机构地区：[1]福建医学院微生物学教研室,福州350004 [2]福建医学院附属协和医院消化内科 [3]福建医学院电镜室

出　　处：《中国人兽共患病杂志》1995年第6期9-12,共4页Chinese Journal of Zoonoses

摘　　要：用7种抗生素对44株临床分离的幽门螺杆菌(H.p)进行耐药性研究,并时其中19株H.p进行质粒检测,发现H.p对氨苄青霉素及痢特灵敏感,对庆大、氟哌酸等5种抗生素出现不同程度耐药现象。质粒检出率为31.6％,质粒与本试验所用抗菌素耐药性无关。研究还发现亚抑菌浓度抗生素可引起H.p发生球形变,本文对H.p的球形变现象及其与耐药性关系进行探讨。In this study, 44 H. pylori strains were isolated from fresh gastric biopsy specimens for their plasmids and drug-resistance to seven antibiotics. The results showed that H. pylori were sensitive to Ampicillin and Furazolidone, while resistant to other five antibiotics at various degrees. Plasmids were detected in 6 out of 19 H. pylori strains (31% ), and relative analysis revealed that plasmid was not associated with drug-resistance. In addition. H. pylori turned to coc-coid form after incubation on agar containing sub-MIC of antibiotic. The author also discussed the relationship between coccoid H. pylori and drug-resistance.

关 键 词：幽门螺杆菌 耐药性 质粒 球形变 

分 类 号：R378.99[医药卫生—病原生物学] R915[医药卫生—基础医学]