黄体功能不全与生殖激素的关系  

Relationship between luteal phase defect and reproductive hormones

作　　者：王红[1] 曹缵孙[1] 杨兆瑞[2] 毛文军[3] 陈晓燕[3] 

机构地区：[1]西安医科大学第一附属医院妇产科,710061 [2]西安医科大学第一附属医院病理科,710061 [3]西安医科大学生殖内分泌研究室

出　　处：《中国实用妇科与产科杂志》1995年第1期21-23,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：本文对22例有排卵不孕妇女于 B 超监测排卵的同时,在卵泡中期、围排卵期和黄体中期测血清 LH、FSH、PRL、E_2、P、T;排卵后第10～14天取子宫内膜行病理学检查。按子宫内膜发育落后于月经周期>2天判断为黄体功能不全(LPD)。比较 LPD 组(n=12)和正常组(n=10)生殖激素值与卵泡直径的差异。结果;FSH 和卵泡期 LH、E_2在两组间无差异,黄体期 LH、E_2、P 水平,LPD 组低于正常组(P<0.05);而 PRL、T 水平,LPD 组均高于正常组(P<0.05)。正常组卵泡直径大于 LPD 组(P<0.05)。结果提示 LPD 的发生与高 PRL、高 T 及黄体期低 LH 有关;卵泡发育不成熟也是 LPD 的原因之一。Serum LH,FSH,E_2,P,T,and PRL were measured during mid-follicular,periovulatory and middle luteal phase of the menstrual cycle,and B ultrasound were performed for detection of ovulation in 22 ovula- tory infertile women.Luteal phase defect(LPD)was definedas endometrial development being more than 2 days out of phase on biopsy.Comparison between the LPD group (n=12) and the normal group (n=10) showed no difference in terms of serum FSH,LH, and E_2 levels in follicular phase (P>0.05).However, in luteal phase,serum levels of LH,E_2,and P in LPD group were lower than in normal group(P<0.05 )whearas PRL and T levels in LPD were higher than in normal group(P<0.05),and the follicular size in LPD group was smaller(P<0.05).The results indi- cated that development of LPD was associated with high levels of PRL,T and low LH in the luteal phase.Abnormal follicuiogenesis may be another causitive factor for LPD.

关 键 词：黄体功能不全 生殖激素 卵泡直径 病理化学 

分 类 号：R711.59[医药卫生—妇产科学]