443例妊娠期肝内胆汁郁积症临床分析  

Intraheptic Cholestasis during Pregnancy:Clinical Analysis of 443 Cases.

作　　者：谈月娣 

机构地区：[1]上海普陀区中心医院妇产科,200062

出　　处：《中国实用妇科与产科杂志》1995年第1期31-32,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：1987年1月至1993年9月我院分娩孕妇12716例,其中妊娠期肝内胆汁郁积症(ICP)443例,发生率3.48%。ICP 主要表现为皮肤瘙痒、黄痘及 SGPT 升高.443例中发生早产85例,发生率为19.2%。死胎13例,死产8例,新生儿早期死亡3例,围产儿病死率为54.2‰.新生儿 Apgar 评分≤7分者48例,占10.8%.新生儿平均体重3082g.本文认为,早期诊断,孕期加强监护,产时严密观察产程进展、胎心变化,羊水情况,积极处理产程是降低 ICP 并发症的有效措施.Totally 12716 pregnancies were delivered in our hopi- tal from January 1987 to September 1993.Among them,443 patients had intraheptic cholestasis of preg- nalcy(ICP)accounting for 3.48% of the pregnan- cies.The main clinical features of ICP were skin irrita- tion,jaundice,and increased serum glutamic-pyruvic transaminase.Eighty-five of the 443 patients had premature labour,accounting for 19.2%.Thirteen had fetal death,8 had stillbirth,and three had neona- tal death.The perinatal mortality was 5.42%.Forty -eight babies had an Apgar score 7 or less,account- ing for 10.8%.Average neonatal weight was 3082 gm.The author suggested that early diagnosis of ICP and intensive monitoring of fetal heart and amniotic fluid during pregancy and labour and prompt treat- ment may reduce the occurrence of complications of ICP.

关 键 词：妊娠 肝 胆汁郁积 临床分析 

分 类 号：R714.255[医药卫生—妇产科学]