妊娠合并肝内胆汁郁积症的甘胆酸值变化及分娩方式探讨  

The change or serum ckolyglycine value and the selection of the way of delivery in pregnant women complicated with intrthepatic cholestasis.

作　　者：江明礼[1] 董玉英[1] 王福淇[1] 张黎铭[1] 

机构地区：[1]上海市第一人民医院

出　　处：《中国实用妇科与产科杂志》1995年第4期221-222,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：本文采用放免测定对６３例妊娠合并肝内胆汁郁积症（ＩＣＰ）的患者进行血清甘胆酸（ＣＧ）含量测定，结果表明ＣＧ值在诊断ＩＣＰ中比转氨酶灵敏，其异常值，前者为１００％，后者为８３％。因此妊娠期瘙痒、ＣＧ值增高或伴有转氨酶及／或胆红素的增高是ＩＣＰ严重程度不同的表现。且ＣＧ值的增高倍数与胎）Ｌ宫内窘迫的发生率有关（Ｐ＜０．０５）。在ＣＧ值异常组中必须动态观察临床和实验室各项指标的变化，用胎儿监护仪，加强产前、产时的胎儿监护，及时破膜，了解羊水性状，以选择适当的分娩方式。bjective: The purpose was to demonstrate thatthe serum conjugated cholic acid was a sensitive indicator reflecting the parenchymatous cell function ofliver. Design: The serum cholyglycine (CG) levels in63 cases of intrahepatic cholestasis of pregnancy(ICP) from January 1990 to April 1992 were detectedby RIA. ResultS:The CG was more sensitive than SGPT and their sensitivity were 100% and 83% respectively, so we can use this test for early diagnosis ofICP. The seventy of ICP escalated with the increasingof CG or SGPT and the serum bilirubin value. The incidence of fetal distress was related to the value of CG(P<0. 05). In abnormal CG group,continuously clinical. and laboratory observation, prenatal and hitrapartum fetal monitoring,timely detecting of amnioticfluid property were mandatory for determining the appropriate way of delivery. Conclusion: The resultssuggest that we can use this test for early diagnosis ofICP.

关 键 词：甘胆酸 肝内胆汁郁积 胎儿窘迫 分娩 妊娠合并症 

分 类 号：R714.255[医药卫生—妇产科学]