脑内胰岛移植治疗Ⅰ型糖尿病  

INTRACEREBRAL PANCREAS ISLET TRANSPLANTATION FOR THE TREATMENT OF TYPE I DIABETES MELLITUS

作　　者：董砚虎[1] 钱捷[1] 王善言[1] 张振兴[1] 逄力男[1] 孔凡介 张贺[1] 韩卫[1] 张增富[1] 王伯孝 王永和[1] 王寿先[1] 季祥武[1] 钱薇[1] 刘登岳[1] 马志根 白林[2] 刘俊芝 赵鑫 

机构地区：[1]山东潍坊市人民医院 [2]山东潍坊医学院组胚室 [3]驻潍54960部队医院外科

出　　处：《中华内分泌代谢杂志》1989年第4期195-198,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：本研究采用培养的人胎儿胰岛组织脑内移植治疗Ⅰ型糖尿病患者10例,其中7例已完全撤离胰岛素治疗达2～13个月,2例每日胰岛素剂量较移植前分别减少37％和64％,病情控制良好,无效者1例。本研究结果表明,脑内胰岛移植治疗Ⅰ型糖尿病临床效果显著,移植物可能在患者脑内成活。Ten cases of type I diabetes mellitus were treated with intracerebral pancreas islet transplantation. In 7 cases insulin has been totally stopped for 2 to 13 months, in other 2 cases the dosages of insulin had a decrease of 37% and 64% than that before transplantation respectively, and good control was achieved in those 9 patients. Only one case had not any improvement. The results showed that it is an effective therapy for type I diabetes mellitus and indicated that the pancreas islet was survived in patient's cerebrum and secreted insulin. No evidence of immunological rejection was found. Long-term follow-up is necessary to find how long the allogenic graft can survive.

关 键 词：Ⅰ型糖尿病 脑内胰岛移植 免疫特许区 

分 类 号：R587.105[医药卫生—内分泌]