超氧化物歧化酶对链脲佐菌素诱发糖尿病自由基代谢的影响  

The effect of superoxide dismutase on metabolism of free radicals in diabetic rat induced by streptozocin

作　　者：赵明 王亦根[1] 张雯[1] 程光宇[1] 吴国荣[1] 

机构地区：[1]解放军第八一医院内分泌科,南京师范大学生物系

出　　处：《中国糖尿病杂志》1995年第1期44-46,共3页Chinese Journal of Diabetes

摘　　要：给链脲佐菌素诱导的糖尿病模型大鼠以超氧化物歧化酶（ＳＯＤ），观察其自由基代谢改变。结果显示：糖尿病模型大鼠血和胰腺组织中ＬＰＯ、ＭＤＡ水平升高，Ｔ－ＳＯＤ、Ｃｕ－Ｚｎ－ＳＯＤ水平低下，和正常对照组相比有显著性差异（Ｐ＜０．０１）。用ＳＯＤ后，ＬＰＯ、ＭＤＡ水平下降，Ｔ－ＳＯＤ、Ｃｕ－Ｚｎ－ＳＯＤ水平上升，和未用药组相比有显著性差异（Ｐ＜０．０１）。而且ＳＯＤ大剂量比小剂量作用更明显。结果表明，ＳＯＤ对改善糖尿病模型大鼠自由基代谢异常有作用。Superoxide dismutase(SOD) was given to diabetic model rat induced by streptozocin.The results showed that compared with control group, the levels of MDA, LPO were higher in diabetic model groups.T-SOD, Cu-Zn-SOD were lower,P<0.01.After administration of SOD, the levels of MDA,LPO decreased in diabetic model groups.T-SOD, Cu-Zn-SOD increased P<0. 01, and the effect of highdose -SOD was more significant than that of low-dose-SOD. Our results showed that SOD might be effective on metabolism of free radicals in diabetic model rat.

关 键 词：糖尿病 超氧化物歧化酶 自由基 

分 类 号：R587.105[医药卫生—内分泌] R977.3[医药卫生—内科学]