GFR、ERPF和RI联合测定对糖尿病肾病诊断价值的探讨  

Evaluation of joint determinations of GFR、ERPF and RI in the diagnosis of diabetic nephropathy

作　　者：赵淑好[1] 林军[1] 王中心[1] 潘时中[1] 严孙杰[1] 杨立勇[1] 汤冰[1] 吴立坚[1] 林好学[1] 

机构地区：[1]福建医学院附属第一医院内分泌科

出　　处：《中国糖尿病杂志》1995年第4期206-209,共4页Chinese Journal of Diabetes

摘　　要：对５１例ＮＩＤＤＭ患者测定了ＧＦＲ、ＥＲＰＦ和ＲＩ值，并与２０例正常人进行比较，结果表明，ＮＩＤＤＭ组中正常白蛋白尿患者ＧＦＲ、ＥＲＰＦ和ＲＩ值均升高（Ｐ＜０．０５），且与空腹血糖水平呈正相关；微量白蛋白尿患者仅ＲＩ降低（Ｐ＜０．０５），ＧＦＲ、ＥＲＰＦ无明显变化；大量白蛋白尿患者ＧＦＲ、ＲＩ均降低（Ｐ＜０．０１）。提示ＧＦＲ、ＥＲＰＦ和ＲＩ联合测定可明确肾功能正常、肾小球高滤过、隐性糖尿病肾病和临床糖尿病肾病等４种状态。To investigate that clinical value of determinations of glomerular filtration rate (GFR)、effective renal plasma flow(ERPF) and renal index(RI) in the diagnosis of diabetic nephropathy,GFR、ERPFand RI were jointly determined in 51 patients with noninsulin-dependent diabetes mellitus(NIDDM) and 20 normal subjects,The results showed that GFR、ERPF and RI were higher in short duration NIDDM patients with normoal buminuria than in normal subjects. GFR and RI had significantly positive correlation with facting blood glucose level. GFR and ERPF in NIDDM patients with microalbuminuria were not significantly changed but RI was markedly decreased as compared with normal subjects, GFR and RI were substantially decreased in NIDDM patients with microalbuminuria.It is concluded that joint measurements of GFR、ERPF and RI can determine the severity of diabetic nephropathy, i.e, the four states of normal renal function、glomerular hyperfiltration、incipient nephropathy and overt clinical nephropathy in the NIDDM.

关 键 词：NIDDM 糖尿病肾病 肾功能 诊断 

分 类 号：R587.204[医药卫生—内分泌]