脑室给予胰升糖素样肽GLP－1（7－36）对大鼠血糖及血糖调节激素的影响  

Effects of intracerebral ventricular GLP-1(7-36) on blood glucose and its regulatory hormones in rats

作　　者：赵咏梅[1] 齐红伟[1] 童文凯 姬志娟[1] 郭育红[1] 盛树力[1] 

机构地区：[1]首都医科大学宣武医院

出　　处：《中国糖尿病杂志》1995年第4期222-224,共3页Chinese Journal of Diabetes

摘　　要：采用给禁食大鼠脑室灌注溶于不同溶剂中的ＧＬＰ－１（７－３６）的方法，观察ＧＬＰ－１在中枢对大鼠血糖及血糖调节激素浓度的影响。结果表明：脑室灌注溶于生理盐水的ＧＬＰ－１与单纯灌注生理盐水相比，血糖无明显变化，但１小时后，血中胰岛素、胰升糖素浓度均明显降低；脑室灌注溶于３０％葡萄糖的ＧＬＰ－１与单纯灌注３０％葡萄糖相比，血糖明显升高，在３０’、４５’、６０’有显著性差异，血中胰岛素浓度明显低于对照组，胰升糖素浓度无变化。这些实验说明ＧＬＰ－１参与了中枢神经系统对胰岛分泌激素功能的调节。After intracerebral ventricular administration of GLP-1 in NS or 30% glucose to rats,their effects on blood glucose and glucose regulatory hormones were observed. The results demonstrated:1. Intracerebral ventricular administration of GLP-1 in NS didn't influence plasma stucose, insulin and glucagon secretion.2. Intracerebral ventricular administration of GLP-1 in 30% glucose increased plasma glucose concentration significantly and decreased insulin concentration,but no change of glucagon concentration. This experiment showed that GLP-1 might participate in CNS regulation of pancreatic islet hormonesecretion.

关 键 词：GLP-1(7-36) 胰岛素 胰升糖素 

分 类 号：R587[医药卫生—内分泌]