潘生丁治疗呼吸道合胞病毒肺炎机制的探讨  

A APPROACH TO MECHANISM OF DIPYRIDAMOLE IN THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS PNEUMONIA

作　　者：潘家华[1] 陈兰举[1] 李清友[1] 楼皖玲[1] 姚敏[1] 

机构地区：[1]蚌埠医学院附属医院儿科,蚌埠医学院组胚教研室

出　　处：《中国微生态学杂志》1995年第1期15-18,共4页Chinese Journal of Microecology

摘　　要：ＢＡＬＢ／Ｃ小鼠５５只，经鼻滴入呼吸道合胞病毒悬液１００μｌ（１０６ＰＦＵ）引起小鼠肺炎。用潘生丁（５０ｍｇ／ｋｇ·ｄ）于不同时间（感染前１天、感染同时及感染后１天）和不同剂量（１００、２５、１２．５ｍｇ／ｋｇ·ｄ）灌胃，共３天。通过病理学和组织化学方法观察鼠肺和脾脏，发生感染后１天（５０ｍｇ／ｋｇ·ｄ）给药组肺泡炎最轻，上皮细胞内病毒颗粒少，浆细胞数量多，脾动脉周围淋巴鞘Ｔ淋巴细胞增殖最轻。提示适量口服潘生丁通过抑制炎症早期Ｔ淋巴细胞增殖，促进分泌特异性抗体的浆细胞生成，减轻免疫损伤使病情改善。Fifty-five BALB/C mice inoculated intranasally with 106PFU ofthe long straiu of respiratory syntial virus developed severepneumonia,Fourty-five randomly mice were administered withdipyridamole 50mg/kgd in different time(one day before infection,at the same time and one day after infection) and different dose(100,25, 12.5mg/kg·d) by oral route for 3 days respectively. The lungand spleen were examined by pathology and histochemistry assay. Ascompared with the control,the lung pathol ogy apeared mild,fewviral pellets in the epitheltial cells of lungs,few lymphocytes and afew plasma cells in the interstitial and proliferation of T lymphocytesin splenic periarterial 1ym-phatic sheath significantly decreased inthe group of one day after infection 50mg/kg·d

关 键 词：哌醇啶 呼吸道合胞病毒 肺炎 

分 类 号：R563.105[医药卫生—呼吸系统] R972.4[医药卫生—内科学]