LC－CW的抗肿瘤作用及其机理的研究  

STUDIES OF ANTITUMOR EFFECTS AND MEHANISMS OF LE-CW

作　　者：侯桂华[1] 曹容华[1] 吴光照[1] 宋静[1] 周亚滨[1] 姜启海[1] 

机构地区：[1]山东医科大学微生物学教研室

出　　处：《中国微生态学杂志》1995年第4期8-10,共3页Chinese Journal of Microecology

摘　　要：提取干酪乳酸杆菌细胞壁成分（ＬＣ－ＣＷ），研究其抗肿瘤作用及其机理。结果表明：１００μｇＬＣ－ＣＷ，ｉｐ，连续４天，可明显抑制小鼠Ｓ１８腹水瘤移植物的生长，抑瘤率为５４％。增强ＩＬ－２诱导的ＬＡＫ杀伤活性，可明显促进小鼠ＮＫ杀伤活性，明显促进小鼠Ｔ细胞转化，促进ＣｏｎＡ和ＰＨＡ－Ｐ诱导的ＩＬ－２产生，促进ＳＩＬ－２Ｒ的减少。研究结果表明ＬＣ－ＣＷ是一种重要的抗肿瘤免疫调节因子。Extract the cell wall components of Lactobacillus casei,studied its arti-tumoreffects and mechanisms.The results revealed that the LC-CW can apparently inhibit thegrowth of tumor in mice,LC-CW enhanced the LAK killing activities induced by recombi-nant IL-2,but it cant induce the LAK killing activities alone LC-CW can promote theNK kiliing activities and T cells proliferation in mice. Also, the results suggested that the LC-CW can increase the production of IL-2 induced by PHA-P(human)and ConA(mice),LC-CW may decrease the releaqe of soluble IL-2 receptors by human peripheralblood lymphocytes alone. The results suggest that the LC-CW may be a important anti-rumor factor

关 键 词：干酪乳酸杆菌 肿瘤 免疫疗法 

分 类 号：R965[医药卫生—药理学] R730.51[医药卫生—药学]