杀虫脒衍生物的合成及其人工抗原的制备  

Synthesis of Hapten and Preparation of Conjugates for the Determination of Chlordimeform by Immunoassay

作　　者：余万俊[1] 鲁长豪[1] 肖志芳[1] 

机构地区：[1]华西医科大学公共卫生学院,四川成都610041

出　　处：《中国卫生检验杂志》1995年第3期131-134,共4页Chinese Journal of Health Laboratory Technology

基　　金：国家教委博士点基金;CMB基金

摘　　要：本文以对硝基苯乙腈和对氯邻甲苯胺为主要原料，经五步反应合成了带苯胺基的杀虫脒衍生物（半抗原）。用ＩＲ、ＨＮＭＲ和ＭＳ证明了产物的结构。经重氮化－偶合反应，将半抗原与载体蛋白偶联制成抗原，为建立杀虫脒的免疫分析法打下了基础。In the present work,a chlordlme form derivative(hapten) with a p-aminobenzyl spacer was synthesized and its structure was confirmed by IR,HNMR and,MS. The hapten was then conjugated to carrier proteins by way of diazotization to form antigen for the purpose of determining chlordimeform residues by immunoassay.

关 键 词：杀虫脒 衍生物 人工抗原 制备 

分 类 号：R392－33[医药卫生—免疫学]