黄芪总黄酮对羟自由基所致V_（79）细胞DNA链断裂损伤的防护作用研究  

The protective effect of total flavonids of astragalus on DNA strand breaks in V_(79)cell caused by hydroxyl radical

作　　者：汪德清[1] 沈文梅[1] 田亚平[1] 刘国廉[1] 杨素霞[1] 周淑珍[1] 孙仲怡[1] 

机构地区：[1]解放军总医院生化科,北京放射医学研究所

出　　处：《中国药理学通报》1995年第4期311-313,共3页Chinese Pharmacological Bulletin

摘　　要：报道黄芪总黄酮对羟自由基所致细胞ＤＮＡ损伤的防护效能。结果表明在黄芪总黄酮浓度为０．４ｇ·Ｌ－１时即有防护作用，当浓度为０．８ｇ·Ｌ－１时对羟自由基所致细胞ＤＮＡ链断裂损伤即有极显著的防护效果。The protective effect of Total Flavonoids of Astragalus (TFA) for DNA strand breaks in V79 Cell caused by hydroxyl radical have been studied by using fluorometric assay of DNA unwinding,Results showed that the breaks was protected by TFA at 0.4g·L-1. When the concentration of TFA increased to 0.8 g·L-1 the significant protective effects was found.

关 键 词：羟自由基 V79细胞 DNA损伤 黄芪总黄酮 FADU 

分 类 号：R286.79[医药卫生—中药学]