8种化合物对洗必泰协同杀菌作用的研究  

STUDY ON THE SYNERGISTIC GERMICIDAL ACTION OF CHLORHEXIDINE WITH EIGHT CHEMICALS

作　　者：袁朝森[1] 牟友诚 张敏丽[1] 

机构地区：[1]军事医学科学院微生物流行病研究所,军事医学科学院卫生学环境医学研究所

出　　处：《中国消毒学杂志》1995年第4期193-198,共6页Chinese Journal of Disinfection

基　　金：国家自然科学基金

摘　　要：经测试，在醇、醛、酚、酮、酪、酸、盐与表面活性剂等８类５１种化合物中各选１种与洗必泰不形成沉淀，且有杀菌作用的化合物与洗必泰进行协同杀灭金黄色葡萄球菌和大肠杆菌试验。其中以含丙醇、苯酚、苯甲酸钠、新洁尔灭等的复方效果较好。文中还报道了成分配比、复方中剩留洗必泰量对杀菌作用的影响。The synergistic germicidal actions of chlorhexidine with eight chemicals belonging to al-cohols,aldehydes,phenols,ketones,esters,acids,salts and surfectants respectively was stu-died in laboratory.The chemicals studied are cinnamaldehyde,propanol,bromogeramine,phenol,sodium bezoate,acetone,diethyl malonate and oxalic acid.Staphylococcus aureus and Escherichia coli were used as test organisms.The results indicated that the chemicals showing good synergistic effect withchlorhexidine on S.aureus and E.only propanol,sodium benzoate,bromogeramine and phenol.The optimal concentrations of chlorhexidine in the compound disinfectants were esti-mated.The relationship between the germicidal efficacy and the quantity of residualchlorhexidine in the compound disinfectant was also discussed.

关 键 词：洗必泰 化合物 协同杀菌作用 醇 醛 酚 酮 

分 类 号：R979.7[医药卫生—药品]