国产阿齐红霉素在大鼠的组织分布及与正常人血浆蛋白结合率研究  

TISSUE DISTRIBUTION AND PLASMS PROTEIN BINDING OF DOMESTIC AZITHROMYCIN

作　　者：陈琼[1] 侯平[1] 许军[1] 盛惊洲 李家泰[1] 

机构地区：[1]北京医科大学临床药理研究所,北京医科大学附一院皮科

出　　处：《中国新药杂志》1995年第4期44-46,共3页Chinese Journal of New Drugs

摘　　要：对阿齐红霉素在大鼠的组织分布及与正常人血浆蛋白结合率进行研究。结果表明：阿齐红霉素在体内能很快分布于大多数脏器和组织中，并较长时间内保持较高的药物浓度。蛋白结合率测定结果表明：阿齐红霉素是一种血浆蛋白结合率较低的药物。The plasma protien binding rates of domestic azithromycin in hu-man obtained form thestudy were 12.90%±2. 14%,11.42%±2.20%and 14.00%± 5. 48% with serum concentration of 2mg/L, 1mg/L and 0.5mg/L respectively. There is no significant difference between them (P> 0. 05 ).Tissue distribution in rat was studied by bioassay. The results showed effective diffusion and combination of azithromycin in many extravascular tissues. Tissue concentration was several hundred times higher than that of serum.

关 键 词：阿齐红霉素 组织分布 蛋白结合率 抗菌素 

分 类 号：R978.15[医药卫生—药品]