冠心病患者尿MHPG·SO＿4、皮质醇和白细胞介素测定  

Psycho-neuro-endocrine-immune respoce in patients with coronary heart disease

作　　者：梁志坚[1] 沈渔 赵友文[1] 王玉凤[1] 郭静萱[1] 

机构地区：[1]北京医科大学精神卫生研究所,北京医科大学第三医院

出　　处：《中国心理卫生杂志》1995年第2期57-59,共3页Chinese Mental Health Journal

摘　　要：为了解应激状态下机体的神经递质──内分泌─—免疫系统功能的变化规律，我们对一组冠心病住院患者的尿ＭＨＰＧ、血浆皮质醇及白细胞介素Ⅱ进行观察，结果发现冠心病亚型、病程、焦虑情绪及不同行为模式均影响其神经──内分泌──免疫反应。其中，尿ＭＨＰＧ与血浆皮质醇变化趋势一致，而ＩＬ－２则与皮质醇相反。对于这类心血管病患者，尿ＭＨＰＧ不如皮质醇及ＩＬ２敏感。Urine MHPG, plasma cortisol and interleukin-2 in 66 patients with coronary heart disease (CHD)were observed and the behavioral pattern of patients were assessed. The results revealed a inreased activities in HPA axis and declined immune function in patients after acute attack of CHD,though many factors,such as the subtype of CHD,the course of disease ,the patients’ anxiety level and behavior pattern, might influence the respnse in neuro-endocrine-immune system, The plasma cortisol and urine MHPG changed in the same direction,while interleukin changed inoppossite direction. For these CHD patients ,plasma cortisol and interleukin-2 appeared to be more sensitive indicatorsof response in system of neuro-endocrine-immune than urine MHPG.

关 键 词：冠心病 尿MHPG 皮质醇 白细胞介素Ⅱ、A型行为模式 

分 类 号：R541.404[医药卫生—心血管疾病]