促甲状腺激素释放激素对兔创伤性休克的影响  

Effect of thyrotropin-releasing hormone(TRH) on traumatic shock in rabbits

作　　者：吴勇杰[1] 杨庆莉[1] 李新芳[1] 孟富敏[1] 吴敏[1] 冯秀梅 

机构地区：[1]兰州医学院药理学教研室

出　　处：《中国药理学通报》1995年第5期409-412,共4页Chinese Pharmacological Bulletin

摘　　要：ＴＲＨ０．２２～２ｍｇ·ｋｇ－１ｉｖ使创伤性休克兔血压迅速回升，持续２０ｍｉｎ基本稳定不变。首次ｉｖＴＲＨ和以０．６７ｍｇ·ｋｇ－１·ｈ－１连续静脉输入使休克兔血压在５ｈ内维持在较高水平，同时提高５ｈ存活率。ＴＲＨ亦能对抗休克时的心率减慢及脉压缩小。但快速ｉｖＴＲＨ明显加速休克兔的死亡。The effect of TRH on traumatic shock in unanesthesized rabbits was studied. iv. injection of 0.22～2 mg· kg-1 bw. TRH rapldly reversed hypotension after traumatic shock induced by hitting the rabbits on the region of musculus triangularis of legs.and caused a rise in mean arterial pressure(MAP). Maximum effect on MAP was observed at 5 min and stable for 30 min following TRH injection.iv.infusion of 0.67 mg·kg-1·h-1 TRH in rabbits following a bolus injection at a dosage above mentioned stablized blood pressure over a higher level than that of control group within 5 hours. TRH also antagonized the slowing-down of heart rate and the narrowing of pulse pressure during shock. Moreover, it improved 5 hour survival of shocked rabbits. The effects indicated that it might be beneficial to use TRH in the treatment of clinical traumatic shock associated with hypotension. But high-speed Injection of 2 mg·kg-1 TRH at a rate of 4 mg· kg-1·mIn-1 caused a more rapid and higher rise of MAP following so fast fall of MAP as to the level obviously lower than that of control group at 15 min following injection; meanwhile it accelerated the death of shockedrabbits, suggesting that the high-speed injection of TRH in clinic should be avoided.

关 键 词：促甲状腺激素 释放激素 创伤性休克 休克 

分 类 号：R977.14[医药卫生—药品] R605.971[医药卫生—药学]